University of Oulu

Bayramoglu, N., Nieminen, M. T., & Saarakkala, S. (2022). Machine learning based texture analysis of patella from X-rays for detecting patellofemoral osteoarthritis. International Journal of Medical Informatics, 157, 104627. https://doi.org/10.1016/j.ijmedinf.2021.104627

Machine learning based texture analysis of patella from X-rays for detecting patellofemoral osteoarthritis

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Author: Bayramoglu, Neslihan1; Nieminen, Miika T.1,2,3; Saarakkala, Simo1,2,3
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
3Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 4.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022050633366
Language: English
Published: Elsevier, 2022
Publish Date: 2022-08-04
Description:

Abstract

Objective:To assess the ability of texture features for detecting radiographic patellofemoral osteoarthritis (PFOA) from knee lateral view radiographs.

Design:We used lateral view knee radiographs from The Multicenter Osteoarthritis Study (MOST) public use datasets (n = 5507 knees). Patellar region-of-interest (ROI) was automatically detected using landmark detection tool (BoneFinder), and subsequently, these anatomical landmarks were used to extract three different texture ROIs. Hand-crafted features, based on Local Binary Patterns (LBP), were then extracted to describe the patellar texture. First, a machine learning model (Gradient Boosting Machine) was trained to detect radiographic PFOA from the LBP features. Furthermore, we used end-to-end trained deep convolutional neural networks (CNNs) directly on the texture patches for detecting the PFOA. The proposed classification models were eventually compared with more conventional reference models that use clinical assessments and participant characteristics such as age, sex, body mass index (BMI), the total Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, and tibiofemoral Kellgren-Lawrence (KL) grade. Atlas-guided visual assessment of PFOA status by expert readers provided in the MOST public use datasets was used as a classification outcome for the models. Performance of prediction models was assessed using the area under the receiver operating characteristic curve (ROC AUC), the area under the precision-recall (PR) curve -average precision (AP)-, and Brier score in the stratified 5-fold cross validation setting.

Results:Of the 5507 knees, 953 (17.3%) had PFOA. AUC and AP for the strongest reference model including age, sex, BMI, WOMAC score, and tibiofemoral KL grade to predict PFOA were 0.817 and 0.487, respectively. Textural ROI classification using CNN significantly improved the prediction performance (ROC AUC = 0.889, AP = 0.714).

Conclusions:We present the first study that analyses patellar bone texture for diagnosing PFOA. Our results demonstrates the potential of using texture features of patella to predict PFOA.

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Series: International journal of medical informatics
ISSN: 1386-5056
ISSN-E: 1872-8243
ISSN-L: 1386-5056
Volume: 157
Article number: 104627
DOI: 10.1016/j.ijmedinf.2021.104627
OADOI: https://oadoi.org/10.1016/j.ijmedinf.2021.104627
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Funding: Multicenter Osteoarthritis Study (MOST) Funding Acknowledgment. MOST is comprised of four cooperative grants (Felson – AG18820; Torner – AG18832, Lewis – AG18947, and Nevitt – AG19069) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by MOST study investigators. This manuscript was prepared using MOST data and does not necessarily reflect the opinions or views of MOST investigators. We would like to acknowledge the strategic funding of the University of Oulu, Infotech Oulu.
Copyright information: © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/