University of Oulu

Le Menn, G., Jabłońska, A., & Chen, Z. (2022). The effects of post-translational modifications on Th17/Treg cell differentiation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1869(6), 119223.

The effects of post-translational modifications on Th17/Treg cell differentiation

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Author: Le Menn, Gwenaëlle1; Jabłońska, Agnieszka2; Zhi Chen1,2
Organizations: 1Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
2Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.2 MB)
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Language: English
Published: Elsevier, 2022
Publish Date: 2022-05-13


Regulatory T (Treg) cells and Th17 cells are subsets of CD4⁺ T cells which play an essential role in immune homeostasis and infection. Dysregulation of the Th17/Treg cell balance was shown to be implicated in the development and progression of several disorders such as autoimmune disease, inflammatory disease, and cancer. Multiple factors, including T cell receptor (TCR) signals, cytokines, metabolic and epigenetic regulators can influence the differentiation of Th17 and Treg cells and affect their balance. Accumulating evidence indicates that the activity of key molecules such as forkhead box P3 (Foxp3), the retinoic acid-related orphan receptor gamma t (RORγt), and signal transducer and activator of transcription (STAT)s are modulated by the number of post-translational modifications (PTMs) such as phosphorylation, methylation, nitrosylation, acetylation, glycosylation, lipidation, ubiquitination, and SUMOylation. PTMs might affect the protein folding efficiency and protein conformational stability, and consequently determine protein structure, localization, and function. Here, we review the recent progress in our understanding of how PTMs modify the key molecules involved in the Th17/Treg cell differentiation, regulate the Th17/Treg balance, and initiate autoimmune diseases caused by dysregulation of the Th17/Treg balance. A better understanding of Th17/Treg regulation may help to develop novel potential therapeutics to treat immune-related diseases.

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Series: Biochimica et biophysica acta. Molecular cell research
ISSN: 0167-4889
ISSN-E: 1879-2596
ISSN-L: 0167-4889
Volume: 1869
Issue: 6
Article number: 119223
DOI: 10.1016/j.bbamcr.2022.119223
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3111 Biomedicine
Funding: The authors were supported by the National Science Centre of Poland Sheng1 grant [Project No. 2018/30/Q/NZ6/00769] and Academy of Finland No. 325965 (Z.C.).
Academy of Finland Grant Number: 325965
Detailed Information: 325965 (Academy of Finland Funding decision)
Copyright information: © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (