University of Oulu

Bay-Jensen, A. C., Mobasheri, A., Thudium, C. S., Kraus, V. B., & Karsdal, M. A. Blood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen and aggrecan markers, Current Opinion in Rheumatology: January 2022 - Volume 34 - Issue 1 - p 54-60 doi: 10.1097/BOR.0000000000000845

Blood and urine biomarkers in osteoarthritis : an update on cartilage associated type II collagen and aggrecan markers

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Author: Bay-Jensen, Anne C.1; Mobasheri, Ali2,3,4,5,6; Thudium, Christian S.1;
Organizations: 1Nordic Bioscience, Herlev, Denmark
2Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
3Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
4University Medical Center Utrecht, Department of Orthopedics, Rheumatology and Clinical Immunology, Utrecht, The Netherlands
5Department of Joint Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
6World Health Organization Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, University of Liege, Liege, Belgium
7Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: Wolters Kluwer, 2022
Publish Date: 2022-05-17


Purpose of review: Osteoarthritis (OA) is a painful disease for which drug development has proven difficult. One major reason for this is the heterogeneity of the disease and the current lack of operationalized means to distinguish various disease endotypes (molecular subtypes). Biomarkers measured in blood or urine, reflecting joint tissue turnover, have been developed and tested during the last decades. In this narrative review, we provide highlights on biomarkers derived from the two most studied and abundant cartilage proteins — type II collagen and aggrecan.

Recent findings: Multiple biomarkers assessing type II collagen degradation and formation, and aggrecan turnover have been developed. Several markers, such as uCTX-II, have been validated for their association with disease severity and prognosis, as well as pharmacodynamically used to describe the mode of action and efficacy of drugs in development. There is a great need for biomarkers for subdividing patients (i.e., endotyping) and recent scientific advances have not yet come closer to achieving this goal.

Summary: There is strong support for using biomarkers for understanding OA, reflecting degradation and formation of the joint tissues, focused on type II collagen and aggrecan. There is still a lack of in vitro diagnostics, in all contexts of use.

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Series: Current opinion in rheumatology
ISSN: 1040-8711
ISSN-E: 1531-6963
ISSN-L: 1040-8711
Volume: 34
Issue: 1
Pages: 54 - 60
DOI: 10.1097/BOR.0000000000000845
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: Nordic Bioscience is a partner, and A.C.B.J. and A.M. work are package leaders in the IMI-APPROACH consortium aiming to validate biomarkers for OA under the grant Agreement n° 115770, ( V.B.K.’ effort for this work is partially supported by grant NIH/NIA P30AG028716.
Copyright information: © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CC BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.