University of Oulu

Torniainen J, Ristaniemi A, Sarin JK, Prakash M, Afara IO, Finnilä MAJ, et al. (2022) Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon. PLoS ONE 17(2):e0263280. https://doi.org/10.1371/journal.pone.0263280

Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon

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Author: Torniainen, Jari1,2; Ristaniemi, Aapo1; Sarin, Jaakko K.1,2,3;
Organizations: 1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
2Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland
3Department of Medical Physics, Medical Imaging Center, Pirkanmaa Hospital District, Tampere, Finland
4A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
5School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia
6Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
7Science Service Center, Kuopio University Hospital, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 4.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022051736118
Language: English
Published: Public Library of Science, 2022
Publish Date: 2022-08-11
Description:

Abstract

Knee ligaments and tendons play an important role in stabilizing and controlling the motions of the knee. Injuries to the ligaments can lead to abnormal mechanical loading of the other supporting tissues (e.g., cartilage and meniscus) and even osteoarthritis. While the condition of knee ligaments can be examined during arthroscopic repair procedures, the arthroscopic evaluation suffers from subjectivity and poor repeatability. Near infrared spectroscopy (NIRS) is capable of non-destructively quantifying the composition and structure of collagen-rich connective tissues, such as articular cartilage and meniscus. Despite the similarities, NIRS-based evaluation of ligament composition has not been previously attempted. In this study, ligaments and patellar tendon of ten bovine stifle joints were measured with NIRS, followed by chemical and histological reference analysis. The relationship between the reference properties of the tissue and NIR spectra was investigated using partial least squares regression. NIRS was found to be sensitive towards the water (R2CV = 0.65) and collagen (R2CV = 0.57) contents, while elastin, proteoglycans, and the internal crimp structure remained undetectable. As collagen largely determines the mechanical response of ligaments, we conclude that NIRS demonstrates potential for quantitative evaluation of knee ligaments.

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Series: PLoS one
ISSN: 1932-6203
ISSN-E: 1932-6203
ISSN-L: 1932-6203
Volume: 17
Issue: 2
Article number: e0263280
DOI: 10.1371/journal.pone.0263280
OADOI: https://oadoi.org/10.1371/journal.pone.0263280
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Funding: Source: Valtion tutkimusrahoitus of Kuopio University Hospital (Kuopion Yliopistollinen Sairaala) Project: 5203111 URL: https://www.psshp.fi/tutkimus/tutkimusrahoitus/valtiontutkimusrahoitus} Statement: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Recipient(s): Jari Torniainen Source: Academy of Finland Project: 315820 URL: https://www.aka.fi/en/ Statement: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Recipient(s): Isaac O. Afara Source: Sigrid Juselius Foundation (Sigrid Juseliuksen Säätiö) URL: https://www.sigridjuselius.fi/en/ Statement: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Recipient(s): Rami K. Korhonen, Aapo Ristaniemi Source: Academy of Finland Project: 324529 URL: https://www.aka.fi/en/ Statement: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Recipient(s): Rami K. Korhonen, Aapo Ristaniemi Source: Academy of Finland Project: 316258 URL: https://www.aka.fi/en/ Statement: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Recipient(s): Mithilesh Prakash.
Copyright information: © 2022 Torniainen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  https://creativecommons.org/licenses/by/4.0/