University of Oulu

Ronkainen, J., Nedelec, R., Atehortua, A., Balkhiyarova, Z., Cascarano, A., Ngoc Dang, V., Elhakeem, A., van Enckevort, E., Goncalves Soares, A., Haakma, S., Halonen, M., Heil, K. F., Heiskala, A., Hyde, E., Jacquemin, B., Keikkala, E., Kerckhoffs, J., Klåvus, A., Kopinska, J. A., … on behalf of the LongITools Project Group. (2022). LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases. Environmental Epidemiology, 6(1), e184.

LongITools : dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

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Author: Ronkainen, Justiina1; Nedelec, Rozenn1; Atehortua, Angelica2,3;
Balkhiyarova, Zhanna4,5,6; Cascarano, Anna2,3; Vien Ngoc Dang2,3; Elhakeem, Ahmed7,8; van Enckevort, Esther9,10; Soares, Ana Goncalves7,8; Haakma, Sido9,10; Halonen, Miia1; Heil, Katharina F.2,3; Heiskala, Anni1; Hyde, Eleanor9,10; Jacquemin, Benedicte11; Keikkala, Elina12,13,14,15; Kerckhoffs, Jules16; Klavus, Anton17; Kopinska, Joanna A.18; Lepeule, Johanna19; Marazzi, Francesca20; Motoc, Irina21; Näätänen, Mari17; Ribbenstedt, Anton22; Rundblad, Amanda23; Savolainen, Otto17,22,24; Simonetti, Valentina25; Eadie, Nina de Toro26; Tzala, Evangelia26; Ulrich, Anna4; Wright, Thomas26; Zarei, Iman17; d'Amico, Enrico25; Belotti, Federico20,27; Brunius, Carl22; Castleton, Christopher28; Charles, Marie-Aline29,30; Gaillard, Romy31,32; Hanhineva, Kati17,32,33; Hoek, Gerard16; Holven, Kirsten B.23,34; Jaddoe, Vincent W. V.31,32; Kaakinen, Marika A.4,5; Kajantie, Eero12,13,14,15,35,36,37; Kavousi, Maryam38; Lakka, Timo39,40,41; Matthews, Jason23; Mortari, Andrea Piano20; Vääräsmäki, Marja12,13,14,15; Voortman, Trudy38; Webster, Claire42; Zins, Marie43; Atella, Vincenzo20,27,44; Bulgheroni, Maria25; Chadeau-Hyam, Marc26; Conti, Gabriella45,46; Evans, Jayne42; Felix, Janine F.31,32; Heude, Barbara29; Järvelin, Marjo-Riitta1,26; Kolehmainen, Marjukka17; Landberg, Rikard22; Lekadir, Karim2,3; Parusso, Stefano28; Prokopenko, Inga4,47,48; de Rooij, Susanne R.21; Roseboom, Tessa21,49; Swertz, Morris9,10; Timpson, Nicholas7,8; Ulven, Stine M.23; Vermeulen, Roel16,50; Juola, Teija1; Sebert, Sylvain1
Organizations: 1Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.
2Univ Barcelona, Artificial Intelligence Med Lab BCN AIM, Barcelona, Spain.
3Univ Barcelona, Dept Math & Comp Sci, Barcelona, Spain.
4Univ Surrey, Sch Biosci & Med, Dept Clin & Expt Med, Sect Stat Multiomics, Guildford, Surrey, England.
5Imperial Coll London, Dept Metab Digest & Reprod, Sect Genet & Genom, London, England.
6Bashkir State Med Univ, Dept Endocrinol, Ufa, Russia.
7Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.
8Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.
9Univ Groningen, Dept Genet, Groningen, Netherlands.
10Univ Groningen, Genom Coordinat Ctr, Groningen, Netherlands.
11Univ Rennes, Sch Adv Studies Publ Hlth EHESP, Res Inst Environm & Occupat Hlth, INSERM,UMR S 1085, Rennes, France.
12Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki, Finland.
13Finnish Inst Hlth & Welf, Populat Hlth Unit, Oulu, Finland.
14Oulu Univ Hosp, PEDEGO Res Unit, MRC Oulu, Oulu, Finland.
15Univ Oulu, Oulu, Finland.
16Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.
17Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
18Sapienza Univ Rome, Dept Social Sci & Econ, Rome, Italy.
19Grenoble Alpes Univ, Inst Adv Biosci, CNRS, INSERM, Grenoble, France.
20Univ Roma Tor Vergata, Ctr Econ & Int Studies, CEIS Tor Vergata, Rome, Italy.
21Univ Amsterdam, Amsterdam Publ Hlth, Epidemiol & Data Sci, Amsterdam UMC, Amsterdam, Netherlands.
22Chalmers Univ Technol, Dept Biol & Biol Engn, Div Food & Nutr Sci, Gothenburg, Sweden.
23Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
24Chalmers Univ Technol, Dept Biol & Biol Engn, Chalmers Mass Spectrometry Infrastruct, Gothenburg, Sweden.
25Ab Acus Srl, R&D Dept, Milan, Italy.
26Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Hosp, London, England.
27Univ Roma Tor Vergata, Dept Econ & Finance, Rome, Italy.
28CyNexo Srl, Trivignano Udinese, Italy.
29Univ Paris, Ctr Res Epidemiol & Stat, INRAE, INSERM, Paris, France.
30INSERM, EFS, Elfe Joint Unit, Ined, Aubervilliers, France.
31Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands.
32Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands.
33Univ Turku, Dept Biochem, Turku, Finland.
34Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Natl Advisory Unit Familial Hypercholesterolemia, Oslo, Norway.
35Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
36Helsinki Univ Hosp, Childrens Hosp, Helsinki, Finland.
37Univ Helsinki, Helsinki, Finland.
38Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.
39Univ Eastern Finland, Inst Biomed Physiol, Kuopio, Finland.
40Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland.
41Kuopio Res Inst Exercise Med, Fdn Res Hlth Exercise & Nutr, Kuopio, Finland.
42Beta Technol Ltd, Doncaster, England.
43INSERM UMS 11, Populat Based Epidemiol Cohorts Unit, Villejuif, France.
44Stanford Univ, Stanford, CA 94305 USA.
45UCL, Dept Econ, London, England.
46Social Res Inst, London, England.
47Univ Lille, Inst Pasteur Lille, CNRS, UMR 8199 EGID, Lille, France.
48Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa, Russia.
49Univ Amsterdam, Amsterdam Reprod & Dev Inst, Amsterdam UMC, Gynaecol & Obstet, Amsterdam, Netherlands.
50Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands.
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
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Language: English
Published: Wolters Kluwer, 2022
Publish Date: 2022-05-17


The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our ”modern” postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases.

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Series: Environmental epidemiology
ISSN: 2474-7882
ISSN-E: 2474-7882
ISSN-L: 2474-7882
Volume: 6
Issue: 1
Article number: e184
DOI: 10.1097/EE9.0000000000000184
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Funding: Supported by the European Commission through the Horizon 2020 research and innovation programme under grant agreement number 874739.
Copyright information: Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.