University of Oulu

Lampainen, K., Shiri, R., Auvinen, J., Karppinen, J., Ryhänen, J., & Hulkkonen, S. (2022). Weight-Related and Personal Risk Factors of Carpal Tunnel Syndrome in the Northern Finland Birth Cohort 1966. Journal of Clinical Medicine, 11(6), 1510.

Weight-related and personal risk factors of carpal tunnel syndrome in the Northern Finland Birth Cohort 1966

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Author: Lampainen, Kaisa1; Shiri, Rahman2; Auvinen, Juha3,4;
Organizations: 1Department of Hand Surgery, Helsinki University Hospital and University of Helsinki, 00014 Helsinki, Finland
2Finnish Institute of Occupational Health, 00032 Helsinki, Finland
3Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014 Oulu, Finland
4Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland
5Rehabilitation Services of South Karelia Social and Health Care District, 53130 Lappeenranta, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2022
Publish Date: 2022-06-28


Background: Excess body mass is a risk factor for carpal tunnel syndrome (CTS), but the mechanisms of this are unclear. This study aimed to evaluate the association between CTS and personal risk factors of body mass index (BMI), waist circumference and waist-to-hip ratio (WHR). Methods: The study sample consisted of the Northern Finland Birth Cohort 1966 (n = 9246). At the age of 31 in 1997 and at the age of 46 in 2012, the participants underwent a clinical examination. Cohort A consisted of complete cases with a follow-up from 1997 to 2012 (n = 4701), and Cohort B was followed up from 2012 to 2018 (n = 4548). The data on diagnosed CTS were provided by the Care Register for Health Care until the end of 2018. Results: After an adjustment for confounding factors, BMI was associated with CTS among women (hazard ratio (HR) 1.47, 95% Cl 0.98–2.20 for overweight women and HR 2.22, 95% Cl 1.29–3.83 for obese women) and among both sexes combined (HR 1.35 95% Cl 0.96–1.90 for overweight and HR 1.98 95% Cl 1.22–3.22 for obese participants). Neither waist circumference nor WHR was associated with CTS. Conclusions: BMI is an independent risk factor for CTS and is more relevant for estimating the increased risk of CTS due to excess body mass than waist circumference or WHR.

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Series: Journal of clinical medicine
ISSN: 2077-0383
ISSN-E: 2077-0383
ISSN-L: 2077-0383
Volume: 11
Issue: 6
Article number: 1510
DOI: 10.3390/jcm11061510
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: Open access funding provided by University of Helsinki. NFBC1966 received financial support from the University of Oulu, Grant no. 65354 and 24000692, Oulu University Hospital, Grant no. 2/97, 8/97 and 24301140, the Ministry of Health and Social Affairs, Grant no. 23/251/97, 160/97, 190/97, the National Institute for Health and Welfare, Helsinki, Grant no. 54121, the Regional Institute of Occupational Health, Oulu, Finland, Grant no. 50621, 54231, the ERDF European Regional Development Fund, Grant no. 539/2010 A31592. This research was funded by a Rehabilitation Foundation Peurunka research grant awarded to K.L., grant number 2021, and the Finnish Medical Foundation grant for S.H., grant number 5302.
Copyright information: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (