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Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children |
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| Author: | Girchenko, Polina1; Robinson, Rachel1; Rantalainen, Ville Juhani1; |
| Organizations: |
1Institute of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, (Haartmaninkatu 3), P.O BOX 21, 00014, Helsinki, Finland 2National Institute for Health and Welfare, Helsinki, Finland 3Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
4Psychology/Welfare Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland
5Department of Psychology, University of Warwick, Coventry, UK 6Department of Psychology, Bielefeld University, Bielefeld, Germany 7Leibniz University of Hannover, Hannover, Germany 8IZA Bonn, Bonn, Germany 9Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland 10Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland 11Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland 12Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 13Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland 14Obstetrics and Gynaecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 15National Institute for Health and Welfare, Public Health Promotion Unit, Helsinki, Finland 16University of Oulu, Oulu, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.2 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022053039326 |
| Language: | English |
| Published: |
Springer Nature,
2022
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| Publish Date: | 2022-06-29 |
| Description: |
AbstractPreterm birth has been linked with postpartum depressive (PPD) disorders and high symptom levels, but evidence remains conflicting and limited in quality. It remains unclear whether PPD symptoms of mothers with preterm babies were already elevated before childbirth, and whether PPD symptoms mediate/aggravate the effect of preterm birth on child mental disorders. We examined whether preterm birth associated with maternal PPD symptoms, depressive symptoms trajectories from antenatal to postpartum stage, and whether PPD symptoms mediated/aggravated associations between preterm birth and child mental disorders. Mothers of preterm (n = 125) and term-born (n = 3033) children of the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction study reported depressive symptoms four times within 8 weeks before and twice within 12 months after childbirth. Child mental and behavioral disorder diagnoses until age 8.4–12.8 years came from medical register. Preterm birth associated with higher PPD symptoms (mean difference = 0.19 SD, 95% CI 0.01, 0.37, p = 0.04), and higher odds (odds ratio = 2.23, 95% CI 1.22, 4.09, p = 0.009) of the mother to belong to a group that had consistently high depressive symptoms levels trajectory from antenatal to postpartum stage. PPD symptoms partially mediated and aggravated the association between preterm birth and child mental disorders. Preterm birth, maternal PPD symptoms and child mental disorders are associated, calling for timely prevention interventions. see all
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| Series: |
Scientific reports |
| ISSN: | 2045-2322 |
| ISSN-E: | 2045-2322 |
| ISSN-L: | 2045-2322 |
| Volume: | 12 |
| Article number: | 947 |
| DOI: | 10.1038/s41598-022-04990-w |
| OADOI: | https://oadoi.org/10.1038/s41598-022-04990-w |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
Funding was provided by European Commission Dynamics of Inequality Across the Life-course: structures and processes (DIAL) (Grant No. 724363), Academy of Finland, European Commission (Grant No. SC1-2016-RTD-733280 RECAP). |
| Copyright information: |
© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |