Zeltz, C., Navab, R., Heljasvaara, R. et al. Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?. J. Cell Commun. Signal. 16, 649–660 (2022). https://doi.org/10.1007/s12079-022-00673-3
Integrin α11β1 in tumor fibrosis : more than just another cancer‑associated fibroblast biomarker?
|Author:||Zeltz, Cédric1; Navab, Roya2; Heljasvaara, Ritva3;|
1Department of Biomedicine, Matrix Biology Group, Centre for Cancer Biomarkers, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
2Princess Margaret Cancer Center, University Health Network, Toronto, ON, M5G 1L7, Canada
3Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5G 1X8, Canada
|Online Access:||PDF Full Text (PDF, 2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2022062850140
|Publish Date:|| 2022-06-28
There is currently an increased interest in understanding the role of the tumor microenvironment (TME) in tumor growth and progression. In this context the role of integrins in cancer-associated fibroblasts (CAFs) will need to be carefully re-evaluated. Fibroblast-derived cells are not only in the focus in tumors, but also in tissue fibrosis as well as in inflammatory conditions. The recent transcriptional profiling of what has been called “the pan-fibroblast cell lineage” in mouse and human tissues has identified novel transcriptional biomarker mRNAs encoding the secreted ECM proteins dermatopontin and collagen XV as well as the phosphatidylinositol-anchored membrane protein Pi16. Some of the genes identified in these fibroblasts scRNA-seq datasets will be useful for rigorous comparative characterizations of fibroblast-derived cell subpopulations. At the same time, it will be a challenge in the coming years to validate these transcriptional mRNA datasets at the protein-(expression) and at tissue-(distribution) levels and to find useful protein biomarker reagents that will facilitate fibroblast profiling at the cell level. In the current review we will focus on the role of the collagen-binding integrin α11β1 in CAFs, summarizing our own work as well as published datasets with information on α11 mRNA expression in selected tumors. Our experimental data suggest that α11β1 is more than just another biomarker and that it as a functional collagen receptor in the TME is playing a central role in regulating collagen assembly and matrix remodeling, which in turn impact tumor growth and metastasis.
Journal of cell communication and signaling
|Pages:||649 - 660|
|Type of Publication:||
A2 Review article in a scientific journal
|Field of Science:||
1182 Biochemistry, cell and molecular biology
Open access funding provided by University of Bergen (incl Haukeland University Hospital). Supported by grants to Donald Gullberg from the Research Council of Norway (Norwegian Centre of Excellence grant, grants 223250) and Nasjonalföreningen for folkhelsen (Project 16216).
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