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Myeloid-related protein 8/14 in plasma and serum in patients with new-onset juvenile idiopathic arthritis in real-world setting in a single center |
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| Author: | Keskitalo, Paula L.1,2,3; Kangas, Salla M.1,3; Sard, Sirja1,2,3; |
| Organizations: |
1PEDEGO Research Unit, University of Oulu, Oulu, Finland 2Department of Pediatrics, Oulu University Hospital, Kajaanintie 50, 90220, Oulu, Finland 3Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
4Research Unit of Biomedicine, University of Oulu, Oulu, Finland
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| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022070150884 |
| Language: | English |
| Published: |
Springer Nature,
2022
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| Publish Date: | 2022-07-01 |
| Description: |
AbstractObjective: The aim of this study was to analyze the usefulness of myeloid-related protein 8/14 (MRP8/14) in the prediction of disease course in a real-world setting for patients with new-onset juvenile idiopathic arthritis (JIA), to identify the relationship between MRP8/14 and disease activity using the physician’s global assessment of disease activity (PGA), and determine whether the MRP8/14 levels measured in serum and plasma are equally useful. Methods: In this prospective follow-up study, 87 new-onset non-systemic JIA patients were studied. Blood and synovial fluid samples were collected prior to any antirheumatic medication use. MRP8/14 was measured from serum (S-MRP8/14), plasma (P-MRP8/14), and synovial fluid samples using ELISA. Results: The baseline MRP8/14 blood levels were significantly higher in patients using synthetic antirheumatic drugs than in patients with no systemic medications at 1 year after diagnosis in serum (mean 298 vs. 198 ng/ml, P < 0.001) and in plasma (mean 291 vs. 137 ng/ml, P = 0.001). MRP8/14 levels at the time of JIA diagnosis were higher in patients who started methotrexate during 1.5-year follow-up compared to those who achieved long-lasting inactive disease status without systemic medications (serum: mean 298 vs. 219 ng/ml, P = 0.006 and plasma: 296 vs. 141 ng/ml, P = 0.001). P-MRP8/14 was the most effective predictive variable for disease activity (by PGA) in linear multivariate regression model (combined to ESR, CRP, leukocytes, and neutrophils), whereas S-MRP8/14 was not significant. Conclusion: Blood MRP8/14 levels at baseline seem to predict disease course in new-onset JIA patients. P-MRP8/14 might be better than S-MRP8/14 when assessing disease activity at the time of JIA diagnosis. see all
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| Series: |
Pediatric rheumatology |
| ISSN: | 1546-0096 |
| ISSN-E: | 1546-0096 |
| ISSN-L: | 1546-0096 |
| Volume: | 20 |
| Issue: | 1 |
| Article number: | 42 |
| DOI: | 10.1186/s12969-022-00701-x |
| OADOI: | https://oadoi.org/10.1186/s12969-022-00701-x |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article. This study was supported by the Alma and K. A. Snellman Foundation, Oulu, Finland; the Finnish Rheumatic Disease Research Foundation; the Finnish Medical Foundation; the Finnish Cultural Foundation; the Finnish Pediatric Research Foundation; and the Päivikki and Sakari Sohlberg Foundation. |
| Copyright information: |
© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://creativecommons.org/licenses/by/4.0/ |