University of Oulu

Kortelainen, S., Harju, T., Juntti, H. et al. Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study. Eur J Pediatr 181, 2263–2272 (2022).

Late effects and survival of children with malignant solid tumours in northern Finland : a single-centre cohort study

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Author: Kortelainen, Sanni1; Harju, Tekla1,2; Juntti, Hanna1,2;
Organizations: 1PEDEGO Research Unit, University of Oulu, Oulu, Finland
2Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
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Language: English
Published: Springer Nature, 2022
Publish Date: 2022-08-25


The global survival rates for childhood cancers are high: approximately 80% of affected children will survive. Nevertheless, the burden of treatment for survivors is also high as three-quarters experience late effects of varying severity following cancer treatment. The aims of this study were to evaluate the treatment-related late effects of patients with childhood solid tumour in northern Finland and to report their survival rates. Our study included 104 patients treated for malignant solid tumours, excluding central nervous system tumours and lymphomas, between 1990 and 2015. Information regarding the type of late effects as well as other clinical data were obtained from the patients’ medical records. Late effects were observed in 65 (63%) patients, and almost half (40%) of the patients displayed more than one late effect. The most common late effect was hearing loss (n = 20). The 5-year survival rate in our study was 75%.

Conclusion: Our results highlight the importance of long-term follow-up for childhood cancer survivors. As survivors age and survival rates improve, late effects and their impact on patient health as well as the value of surveillance must be considered.

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Series: European journal of pediatrics
ISSN: 0340-6199
ISSN-E: 1432-1076
ISSN-L: 0340-6199
Volume: 181
Issue: 6
Pages: 2263 - 2272
DOI: 10.1007/s00431-022-04399-7
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health
Funding: Open Access funding provided by University of Oulu including Oulu University Hospital. This study was funded by Finnish governmental research funds (VTR)
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