University of Oulu

Urbiola-Salvador, V., Miroszewska, D., Jabłońska, A., Qureshi, T., & Chen, Z. (2022). Proteomics approaches to characterize the immune responses in cancer. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1869(8), 119266.

Proteomics approaches to characterize the immune responses in cancer

Saved in:
Author: Urbiola-Salvador, Víctor1; Miroszewska, Dominika1; Jabłońska, Agnieszka1;
Organizations: 1Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Poland
2Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.6 MB)
Persistent link:
Language: English
Published: Elsevier, 2022
Publish Date: 2022-09-08


Despite the dynamic development of cancer research, annually millions of people die of cancer. The human immune system is the major ‘guard’ against tumor development. Unfortunately, cancer cells have the ability to evade the immune system and continue to grow. The proper understanding of the intricate immune response in tumorigenesis remains the holy grail of cancer immunology and designing effective immunotherapy. To decode the immune responses in cancer, in recent years, proteomics studies have received considerable attention. Proteomics studies focus on the detection and quantification of proteins, which are the effectors of biological functions, and as such, are proven to reflect the cell state more accurately, in comparison to genomic or transcriptomic studies. In this review, we discuss the proteomics studies applied to characterize the immune responses in cancer and tumor immune microenvironment heterogeneity. Further, we describe emerging single-cell proteomics approaches that have the potential to be applied in cancer immunity studies.

see all

Series: Biochimica et biophysica acta. Molecular cell research
ISSN: 0167-4889
ISSN-E: 1879-2596
ISSN-L: 0167-4889
Volume: 1869
Issue: 8
Article number: 119266
DOI: 10.1016/j.bbamcr.2022.119266
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: The authors were supported by the National Science Centre, Poland [Sheng 1: 2018/30/Q/NZ6/] and Academy of Finland No. 325965 (Z.C.).
Academy of Finland Grant Number: 325965
Detailed Information: 325965 (Academy of Finland Funding decision)
Copyright information: © 2022 The Authors. This is an open access article under the CC BY-NC-ND license (