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Emerging histopathologic markers in early-stage oral tongue cancer : a systematic review and meta-analysis |
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| Author: | Elseragy, Amr1,2,3; Bello, Ibrahim O.3,4; Wahab, Awais2,3; |
| Organizations: |
1Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland 2Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland 3Department of Pathology, University of Helsinki, Helsinki, Finland
4Department of Oral Medicine and Diagnostic Sciences, King Saud University College of Dentistry, Riyadh, Saudi Arabia
5Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil 6Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil 7Department of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland 8Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden 9Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland 10Institute of Biomedicine, Pathology, University of Turku, Turku, Finland 11Turku University Central Hospital, Turku, Finland 12Faculty of Dentistry, Misurata University, Misurata, Libya |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 5.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022090957956 |
| Language: | English |
| Published: |
John Wiley & Sons,
2022
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| Publish Date: | 2022-09-09 |
| Description: |
AbstractAlthough there are many histopathologic prognosticators, grading of early oral tongue squamous cell carcinoma (OTSCC) is still based on morphological cell differentiation which has low prognostic value. Here we summarize the emerging histopathological markers showing powerful prognostic value, but are not included in pathology reports. Using PubMed, Scopus, Ovid Medline, and Web of Science databases, a systematic literature search was preformed to identify early OTSCC studies that investigated the prognostic significance of hematoxylin–eosin-based histopathologic markers. Our meta-analysis showed that tumor budding was associated with overall survival (hazard ratio [HR] 2.32; 95% CI 1.40–3.84; p < 0.01) and disease-specific survival (DSS) (1.89; 95% CI 1.13–3.15; p = 0.02). Worst pattern of invasion was associated with disease-free survival (DFS) (1.95; 95% CI 1.04–3.64; p = 0.04). Tumor–stroma ratio was also associated with DFS (1.75, 95% CI 1.24–2.48; p < 0.01) and DSS (1.69; 95% CI 1.19–2.42; p < 0.01). Tumor budding, worst pattern of invasion, and tumor–stroma ratio have a promising prognostic value in early OTSCC. The evaluation and reporting of these markers is cost-effective and can be incorporated in daily practice. see all
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| Series: |
Head & neck |
| ISSN: | 1043-3074 |
| ISSN-E: | 1097-0347 |
| ISSN-L: | 1043-3074 |
| Volume: | 44 |
| Issue: | 6 |
| Pages: | 1481 - 1491 |
| DOI: | 10.1002/hed.27022 |
| OADOI: | https://oadoi.org/10.1002/hed.27022 |
| Type of Publication: |
A2 Review article in a scientific journal |
| Field of Science: |
3122 Cancers 3111 Biomedicine |
| Subjects: | |
| Funding: |
Cancer Society of Finland; Helsinki University Central Hospital; Jane and Aatos Erkko Foundation; Oulu University Hospital MRC; Sigrid Juselius Foundation. |
| Copyright information: |
© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |