University of Oulu

Neprokin A, Broadway C, Myllylä T, Bykov A, Meglinski I. Photoacoustic Imaging in Biomedicine and Life Sciences. Life. 2022; 12(4):588.

Photoacoustic imaging in biomedicine and life sciences

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Author: Neprokin, Alexey1; Broadway, Christian2; Myllylä, Teemu1,3;
Organizations: 1Opto-Electronics and Measurements, ITEE, University of Oulu, P.O. Box 4500, 90570 Oulu, Finland
2College of Engineering and Physical Sciences, Aston University, Birmingham B4 7ET, UK
3Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, P.O. Box 4500, 90014 Oulu, Finland
4Department of Histology, Cytology and Embryology, Institute of Clinical Medicine N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia
5Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, 634050 Tomsk, Russia
6REC Fundamental and Applied Photonics, Nanophotonics, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 13 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2022
Publish Date: 2022-09-15


Photo-acoustic imaging, also known as opto-acoustic imaging, has become a widely popular modality for biomedical applications. This hybrid technique possesses the advantages of high optical contrast and high ultrasonic resolution. Due to the distinct optical absorption properties of tissue compartments and main chromophores, photo-acoustics is able to non-invasively observe structural and functional variations within biological tissues including oxygenation and deoxygenation, blood vessels and spatial melanin distribution. The detection of acoustic waves produced by a pulsed laser source yields a high scaling range, from organ level photo-acoustic tomography to sub-cellular or even molecular imaging. This review discusses significant novel technical solutions utilising photo-acoustics and their applications in the fields of biomedicine and life sciences.

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Series: Life
ISSN: 2075-1729
ISSN-E: 2075-1729
ISSN-L: 2075-1729
Volume: 12
Issue: 4
Article number: 588
DOI: 10.3390/life12040588
Type of Publication: A1 Journal article – refereed
Field of Science: 213 Electronic, automation and communications engineering, electronics
217 Medical engineering
3111 Biomedicine
Funding: Authors acknowledge the support from the INFOTECH and the Academy of Finland (project 325097). This work was also partially financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers “Digital biodesign and personalized healthcare” N∘: 075-15-2020-926.
Academy of Finland Grant Number: 325097
Detailed Information: 325097 (Academy of Finland Funding decision)
Copyright information: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (