University of Oulu

C, L., C, R., G, G. et al. Cost of illness of oral lichen planus: a multicenter university hospital–based outpatient observational study. Clin Oral Invest 26, 3865–3873 (2022).

Cost of illness of oral lichen planus : a multicenter university hospital-based outpatient observational study

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Author: C., Lajolo1; C., Rupe1; G., Gioco1;
Organizations: 1Head and Neck Department, “Fondazione Policlinico Universitario A. Gemelli – IRCCS”, School of Dentistry, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168, Rome, Italy
2Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy
3Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138, Naples, Italy
4Cancer and Translational Medicine Research Unit, University of Oulu, 90220, Oulu, Finland
5Institute of Dentistry, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio Campus, Kuopio, Finland
6Department of Oral and Maxillofacial Diseases and Oral Health Teaching Clinic, Kuopio University Hospital, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Springer Nature, 2022
Publish Date: 2022-09-15


Objectives: To estimate the economic costs of oral lichen planus (OLP) through a multicenter university hospital–based outpatient study conducted in Italy and Finland.

Materials and methods: A multicenter retrospective study was conducted on patients affected by OLP to evaluate the economic cost of managing the disease. Direct costs concerning diagnostic procedures, therapeutic management, and follow-up visits were obtained from clinical records. Statistics was performed with IBM SPSS Statistics.

Results: One hundred and eight patients with a confirmed diagnosis of OLP (81 women and 27 men), 58 Italians and 50 Finnish, were enrolled in this study. The mean annual cost was 1087.2 euros per patient. The mean annual cost was higher in Finnish than in Italian cohort (1558.7 euros vs. 680.7 euros—p < 0.05). Within the Italian cohort, the local immunosuppressive therapy group and atrophic and erosive OLP type had a higher cost (p < 0.05). Within the Finnish cohort, the local immunosuppressive therapy group had a higher cost (p < 0.05).

Conclusions: OLP-related costs are very similar to other chronic oral disorders (i.e., periodontitis) with differences between investigated countries. Moreover, patients with more severe clinical features, who need immunosuppressive therapy, are facing more expensive costs.

Clinical relevance: In this multicenter cost of illness study, we estimated the direct health care costs of OLP and we found that patients with more severe clinical features, who therefore need symptomatic therapy, are facing more expensive costs.

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Series: Clinical oral investigations
ISSN: 1432-6981
ISSN-E: 1436-3771
ISSN-L: 1432-6981
Volume: 26
Issue: 5
Pages: 3865 - 3873
DOI: 10.1007/s00784-021-04353-1
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
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