Casula, V., Tajik, B. E., Kvist, J., Frobell, R., Haapea, M., Nieminen, M. T., Gauffin, H., & Englund, M. (2022). Quantitative evaluation of the tibiofemoral joint cartilage by T2 mapping in patients with acute anterior cruciate ligament injury vs contralateral knees: Results from the subacute phase using data from the NACOX study cohort. Osteoarthritis and Cartilage, 30(7), 987–997. https://doi.org/10.1016/j.joca.2022.02.623
Quantitative evaluation of the tibiofemoral joint cartilage by T2 mapping in patients with acute anterior cruciate ligament injury vs contralateral knees : results from the subacute phase using data from the NACOX study cohort
|Author:||Casula, Victor1,2; Tajik, B.E.3; Kvist, J.4,5;|
1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
3Department of Orthopedics and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
4Unit of Physiotherapy, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
5Center for Medical Image Science and Visualization (CMIV), Department of Health, Medicine and Caring Sciences, Linköping University, Sweden
6Orthopedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
7Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
8Clinical Epidemiology Unit, Orthopedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
|Online Access:||PDF Full Text (PDF, 2.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2022092059688
|Publish Date:|| 2022-09-20
Objective: Immediate cartilage structural alterations in the acute phase after an anterior cruciate ligament (ACL) rupture may be a precursor to posttraumatic osteoarthritis (PTOA) development. Our aim was to describe changes in cartilage matrix in the subacute phase of the acutely ACL-injured knee compared to the contralateral uninjured knee.
Design: Participants (n = 118) aged 15–40 years with an acute ACL injury were consecutively included in subacute phase after acute ACL-injury and underwent MRI (mean 29 days post trauma) of both knees. Mean T2 relaxation times, T2 spatial coefficient of variation and cartilage thickness were determined for different regions of the tibiofemoral cartilage. Differences between the acutely ACL-injured and uninjured knee were evaluated using Wilcoxon signed-rank test.
Results: T2 relaxation time in injured knees was increased in multiple cartilage regions from both medial and lateral compartment compared to contralateral knees, mostly in medial trochlea and posterior tibia (P-value<0.001). In the same sites of injured knees, we observed significantly thinner cartilage. Moreover, injured knees presented shorter T2 relaxation time in superficial cartilage on lateral central femur and trochlea (P-value<0.001), and decreased T2 spatial coefficient of variation in lateral trochlea and load bearing regions of medial-central femoral condyle and central tibia in both compartments.
Conclusions: Small but statistically significant differences were observed in the subacute phase between ACL-injured and uninjured knee in cartilage T2 relaxation time and cartilage thickness. Future longitudinal observations of the same cohort will allow for better understanding of early development of PTOA.
Osteoarthritis and cartilage
|Pages:||987 - 997|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3126 Surgery, anesthesiology, intensive care, radiology
The NACOX-cohort study is supported by the Swedish Research Council, the Swedish Research Council for Sport Science, the Medical Research Council of Southeast, ALF Grants Region Östergötland, ALF Grants Region Skåne, and Jane & Aatos Erkko Foundation. The funders had no role in the analyses of data, interpretation of results, writing of the manuscript, or the decision to submit for publication.
Supplementary data to this article can be found online at https://doi.org/10.1016/j.joca.2022.02.623.
© 2022 The Author(s). This is an open access article under the CC BY license