University of Oulu

Koskela, Antti MD, PhD; Ducatman, Alan MD; Schousboe, John T. MD, PhD; Nahhas, Ramzi W. PhD; Khalil, Naila PhD. Perfluoroalkyl Substances and Abdominal Aortic Calcification. Journal of Occupational and Environmental Medicine: April 2022 - Volume 64 - Issue 4 - p 287-294 doi: 10.1097/JOM.0000000000002479

Perfluoroalkyl substances and abdominal aortic calcification

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Author: Koskela, Antti1; Ducatman, Alan2; Schousboe, John T.3;
Organizations: 1Cancer Research and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Finland
2West Virginia University School of Public Health, Morgantown, West Virginia
3Park Nicollet Osteoporosis Center and Health Partners Institute and Division of Health Policy and Management, University of Minnesota, Minneapolis, Minnesota
4Department of Population and Public Health Sciences, Boonshoft School of Medicine, Wright State University, Dayton, Ohio
5Department of Psychiatry, Boonshoft School of Medicine, Wright State University, Dayton, Ohio
Format: article
Version: accepted version
Access: embargoed
Persistent link:
Language: English
Published: Wolters Kluwer, 2022
Publish Date: 2023-04-01


Objectives: To evaluate if serum perfluoroalkylated substances (PFAS) were associated with abdominal aortic calcification (AAC).

Methods: We used weighted logistic regression to investigate the gender-specific association between PFAS serum levels and AAC more than or equal to 6 from dual-energy X-ray absorptiometry (DXA) scans of the thoraco-lumbar spine from National Health and Nutrition Examination Survey 2013–2014 survey participants aged more than or equal to 40 years.

Results: After adjusting for confounding, none of log-transformed perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS), or perfluorononanoic acid (PFNA) were significantly associated with AAC for either men or women (adjusted odds ratios [ORs] ranged from 0.80 to 1.33, P> 0.05 each). For PFOA and PFOS, the association was positive only in women (although the difference was not statistically significant in either case).

Conclusions: These findings do not provide general support for a relationship of PFAS exposure to AAC, although the results show a need for gender-specific consideration in a larger dataset.

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Series: Journal of occupational and environmental medicine
ISSN: 1076-2752
ISSN-E: 1536-5948
ISSN-L: 1076-2752
Volume: 64
Issue: 4
Pages: 287 - 294
DOI: 10.1097/JOM.0000000000002479
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Copyright information: © 2022 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited. The final authenticated version is available online at