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Genetic and observational evidence : no independent role for cholesterol efflux over static high-density lipoprotein concentration measures in coronary heart disease risk assessment |
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| Author: | Kuusisto, Sanna1,2,3,4; Karjalainen, Minna K.1,2,4,5; Tillin, Therese6; |
| Organizations: |
1Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland 2Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland 3NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
4Biocenter Oulu, University of Oulu, Oulu, Finland
5Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland 6MRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK 7Nightingale Health Plc., Helsinki, Finland 8Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK 9Department of Clinical Physiology, Tampere University Hospital and Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland 10Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland 11Department of Medicine, University of Turku, Turku, Finland 12Division of Medicine, Turku University Hospital, Turku, Finland 13Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland 14Estonian Genome Center, University of Tartu, Tartu, Estonia 15Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland 16Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland 17Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland 18Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland 19Unit of Primary Health Care, Oulu University Hospital (OYS), Oulu, Finland 20Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK 21Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022092360012 |
| Language: | English |
| Published: |
John Wiley & Sons,
2022
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| Publish Date: | 2022-09-23 |
| Description: |
AbstractBackground: Observational findings for high-density lipoprotein (HDL)-mediated cholesterol efflux capacity (HDL-CEC) and coronary heart disease (CHD) appear inconsistent, and knowledge of the genetic architecture of HDL-CEC is limited. Objectives: A large-scale observational study on the associations of HDL-CEC and other HDL-related measures with CHD and the largest genome-wide association study (GWAS) of HDL-CEC. Participants/Methods: Six independent cohorts were included with follow-up data for 14,438 participants to investigate the associations of HDL-related measures with incident CHD (1,570 events). The GWAS of HDL-CEC was carried out in 20,372 participants. Results: HDL-CEC did not associate with CHD when adjusted for traditional risk factors and HDL cholesterol (HDL-C). In contradiction, almost all HDL-related concentration measures associated consistently with CHD after corresponding adjustments. There were no genetic loci associated with HDL-CEC independent of HDL-C and triglycerides. Conclusions: HDL-CEC is not unequivocally associated with CHD in contrast to HDL-C, apolipoprotein A-I, and most of the HDL subclass particle concentrations. see all
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| Series: |
Journal of internal medicine |
| ISSN: | 0954-6820 |
| ISSN-E: | 1365-2796 |
| ISSN-L: | 0954-6820 |
| Volume: | 292 |
| Issue: | 1 |
| Pages: | 146 - 153 |
| DOI: | 10.1111/joim.13479 |
| OADOI: | https://oadoi.org/10.1111/joim.13479 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3142 Public health care science, environmental and occupational health 3111 Biomedicine 3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
This study was funded by the EU, Academy of Finland, Social Insurance Institution of Finland, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation for Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation; Emil Aaltonen Foundation, Yrjö Jahnsson Foundation, Novo Nordisk Foundation, and others. The funders had no role in study design or reporting. |
| Copyright information: |
© 2022 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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https://creativecommons.org/licenses/by/4.0/ |