University of Oulu

Joham, AE, Piltonen, T, Lujan, ME, Kiconco, S, Tay, CT. Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2022; 97: 165- 173. doi:10.1111/cen.14757

Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome

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Author: Joham, Anju E.1,2; Piltonen, Terhi3; Lujan, Marla E.4;
Organizations: 1Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
2Department of Diabetes and Vascular Medicine, Monash Health, Melbourne, Victoria, Australia
3Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
4Division of Nutritional Sciences, Colleges of Human Ecology and Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: John Wiley & Sons, 2022
Publish Date: 2022-09-27


Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting 8%–13% of reproductive‐aged women. The aetiology of the syndrome is complex, with genetic susceptibility, androgen exposure in early life and adiposity related dysfunction leading to perturbance in hypothalamic–ovarian function. PCOS clinical features are heterogeneous, with manifestations arising even in early adolescence, developing into multisystem reproductive, metabolic and psychological manifestations in adulthood. In this review, we will discuss challenges in the diagnosis of PCOS and understanding of the natural history of PCOS.

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Series: Clinical endocrinology
ISSN: 0300-0664
ISSN-E: 1365-2265
ISSN-L: 0300-0664
Volume: 97
Issue: 2
Pages: 165 - 173
DOI: 10.1111/cen.14757
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3123 Gynaecology and paediatrics
Copyright information: © 2022 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.