University of Oulu

Smith, Anne PhDa; Hancock, Mark PhDb; O’Hanlon, Susan MBBS, FRANZCRc,d; Krieser, Michael MBBS, FRANZCRc,d; O’Sullivan, Peter PhDa; Cicuttini, Flavia PhDe; Straker, Leon PhDa; Adler, Brendan MBBS, FRANZCRc; Wang, YuanYuan PhDe; Karppinen, Jaro PhDf,g; Samartzis, Dino PhDh; Beales, Darren PhDa; Coenen, Pieter PhDi; Kent, Peter PhDa,j. The Association Between Different Trajectories of Low Back Pain and Degenerative Imaging Findings in Young Adult Participants Within The Raine Study. SPINE: February 01, 2022 - Volume 47 - Issue 3 - p 269-276 doi: 10.1097/BRS.0000000000004171

The association between different trajectories of low back pain and degenerative imaging findings in young adult participants within the Raine Study

Saved in:
Author: Smith, Anne1; Hancock, Mark2; O’Hanlon, Susan3,4;
Organizations: 1School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia
2Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
3Envision Medical Imaging, Perth, Australia
4Fiona Stanley Hospital, Perth, Australia
5School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
6Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
7Rehabilitation Services of South Karelia Social and Health Care District, Lappeenranta, Finland
8Department of Orthopaedic Surgery, RUSH University, USA
9Amsterdam UMC, Vrije Universiteit, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
10Center for Muscle and Joint Health, University of Southern Denmark, Odense, Denmark
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2022092960429
Language: English
Published: Wolters Kluwer, 2022
Publish Date: 2023-02-01
Description:

Abstract

Study design: Case-control study.

Objective: Investigate the association between lumbar spine magnetic resonance imaging (MRI) findings and 5-year trajectories of low back pain (LBP) in young Australian adults.

Summary of Background Data: The association between lumbar spine imaging findings and LBP remains unclear due to important limitations of previous research, such as a lack of clearly defined LBP phenotypes and inadequate controlling for age, which may substantially affect the association.

Methods: Seventy-eight “case” participants with a previously identified “consistent high disabling LBP” trajectory from age 17 to 22 years and 78 “control” participants from a trajectory with consistently low LBP over the same time period, matched for sex, body mass index, physical activity levels, and work physical demands, were identified from Gen2 Raine Study participants. At age 27, participants underwent a standardized lumbar MRI scan, from which 14 specific MRI phenotypes were identified. Primary analyses used unconditional logistic regression, adjusting for covariates used in the matching process, to investigate the relationship between presence of each imaging finding and being a case or control. Secondary analyses explored those relationships based on the number of spinal levels with each MRI finding.

Results: The odds for being a case compared with a control were higher in those with disc degeneration (Pfirrmann grade ≥ 3; OR = 3.21, 95% CI: 1.60‐6.44; P = 0.001) or those with a herniation (OR = 1.90, 95% CI: 0.96‐3.74; P - 0.065). We also found that the association became substantially stronger when either disc degeneration or herniation was present at two or more spinal levels (OR = 5.56, 95% CI: 1.97‐15.70; P = 0.001, and OR = 5.85, 95% CI: 1.54‐22.25; P = 0.009, respectively). The other investigated MRI findings were not associated with greater odds of being a case.

Conclusions: Lumbar disc degeneration and herniation may be important contributors to disabling LBP in young adults. Further investigation of their potential prognostic and causal roles is indicated.

see all

Series: Spine
ISSN: 0362-2436
ISSN-E: 1528-1159
ISSN-L: 0362-2436
Volume: 47
Issue: 3
Pages: 269 - 276
DOI: 10.1097/BRS.0000000000004171
OADOI: https://oadoi.org/10.1097/BRS.0000000000004171
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Copyright information: © 2021 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. This is a pre-copyedited, author-produced version of an article accepted for publication in Spine. The published version of record Smith, Anne PhDa; Hancock, Mark PhDb; O’Hanlon, Susan MBBS, FRANZCRc,d; Krieser, Michael MBBS, FRANZCRc,d; O'Sullivan, Peter PhDa; Cicuttini, Flavia PhDe; Straker, Leon PhDa; Adler, Brendan MBBS, FRANZCRc; Wang, YuanYuan PhDe; Karppinen, Jaro PhDf,g; Samartzis, Dino PhDh; Beales, Darren PhDa; Coenen, Pieter PhDi; Kent, Peter PhDa,j. The Association Between Different Trajectories of Low Back Pain and Degenerative Imaging Findings in Young Adult Participants Within The Raine Study. SPINE: February 01, 2022 - Volume 47 - Issue 3 - p 269-276 doi: 10.1097/BRS.0000000000004171 is available online at: https://doi.org/10.1097/BRS.0000000000004171.