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Association of lumbar disc degeneration with low back pain in middle age in the Northern Finland Birth Cohort 1966 |
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| Author: | Mertimo, Teija1,2; Karppinen, Jaro2,3,4; Niinimäki, Jaakko3,5; |
| Organizations: |
1Faculty of Medicine and Health Technology, Tampere University Hospital and University of Tampere, P.O. Box 607, FI-33014, Tampere, Finland 2Center for Life Course Health Research, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland 3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland
4Rehabilitation Services of South Karelia Social and Health Care District, Lappeenranta, Finland
5Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland 6Department of Radiology, Turku University Hospital, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland 7Department of Rehabilitation and Psychosocial Support, Tampere University Hospital, P.O. Box 2000, FI-33521, Tampere, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.9 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022092960472 |
| Language: | English |
| Published: |
Springer Nature,
2022
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| Publish Date: | 2022-09-29 |
| Description: |
AbstractBackground: Although it has been suggested that lumbar disc degeneration (LDD) is a significant risk factor for low back pain (LBP), its role remains uncertain. Our objective was to clarify the association between LDD and LBP and whether mental distress modifies the association. Methods: Participants of a birth cohort underwent 1.5-T lumbar magnetic resonance imaging at the age of 47. The association between the sum score of LDD (Pfirrmann classification, range 0–15) and LBP (categorized into “no pain”, “mild-to-moderate pain”, “bothersome-and-frequent pain”) was assessed using logistic regression analysis, with sex, smoking, body mass index, physical activity, occupational exposure, education, and presence of Modic changes and disc herniations as confounders. The modifying role of mental distress (according to the Hopkins Symptom Check List-25 [HSCL-25], the Beck Depression Inventory and the Generalized Anxiety Disorder Scale) in the association was analyzed using linear regression. Results: Of the study population (n = 1505), 15.2% had bothersome and frequent LBP, and 29.0% had no LBP. A higher LDD sum score increased the odds of belonging to the “mild-to-moderate pain” category (adjusted OR corresponding to an increase of one point in the LDD sum score 1.11, 95% CI 1.04–1.18, P = 0.003) and the “bothersome-and-frequent pain” category (adjusted OR 1.20, 95% CI 1.10–1.31, P < 0.001), relative to the “no pain” category. Mental distress significantly modified the association between LDD and LBP, as a linear positive association was consistently observed among individuals without mental distress according to HSCL-25 (adjusted B 0.16, 95% CI 0.07–0.26, P < 0.001), but not among individuals with higher mental distress. Conclusions: LDD was significantly associated with both mild-to-moderate and bothersome-and-frequent LBP. However, the co-occurrence of mental distress diminished the association between LDD and LBP bothersomeness. Our results strongly suggest that mental symptoms affect the pain experience. see all
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| Series: |
BMC musculoskeletal disorders |
| ISSN: | 1471-2474 |
| ISSN-E: | 1471-2474 |
| ISSN-L: | 1471-2474 |
| Volume: | 23 |
| Issue: | 1 |
| Article number: | 359 |
| DOI: | 10.1186/s12891-022-05302-z |
| OADOI: | https://oadoi.org/10.1186/s12891-022-05302-z |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3126 Surgery, anesthesiology, intensive care, radiology |
| Subjects: | |
| Funding: |
The Northern Finland Birth Cohort 1966 study received financial support from: -University of Oulu, Oulu, Finland (Grant no. 65354, 24000692). -Oulu University Hospital, Oulu, Finland (Grant no. 2/97, 8/97, 24301140). -European Regional Development Fund (Grant no. 539/2010 A31592). This study was financially supported by the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital/ Project No. 9AA024. |
| Copyright information: |
© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://creativecommons.org/licenses/by/4.0/ |