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Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer |
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| Author: | Elomaa, Hanna1,2; Ahtiainen, Maarit3; Väyrynen, Sara A.4; |
| Organizations: |
1Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland 2Department of Education and Research, Central Finland Health Care District, Jyväskylä, Finland 3Department of Pathology, Central Finland Health Care District, Jyväskylä, Finland
4Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
5Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA 6Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA 7Broad Institute of MIT and Harvard, Cambridge, MA, USA 8Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, MA, USA 9Surgery Research Unit, Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland 10Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland 11Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland 12Applied Tumor Genomics Research Program, University of Helsinki, Helsinki, Finland 13Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland 14Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022102162732 |
| Language: | English |
| Published: |
Springer Nature,
2022
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| Publish Date: | 2022-10-21 |
| Description: |
AbstractBackground: Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell co-localisation and T cell densities. Methods: We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identified to calculate T cell densities (to derive T cell density score) and G-cross function values, estimating the likelihood of tumour cells being co-located with T cells within 20 µm radius (to derive T cell proximity score). Results: High T cell proximity score associated with longer cancer-specific survival in both the study cohort [adjusted HR for high (vs. low) 0.33, 95% CI 0.20–0.52, Ptrend < 0.0001] and the validation cohort [adjusted HR for high (vs. low) 0.15, 95% CI 0.05–0.45, Ptrend < 0.0001] and its prognostic value was independent of T cell density score. Conclusions: The spatial point pattern analysis of tumour cell-T cell co-localisation could provide detailed information on colorectal cancer prognosis, supporting the value of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker. see all
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| Series: |
British journal of cancer |
| ISSN: | 0007-0920 |
| ISSN-E: | 1532-1827 |
| ISSN-L: | 0007-0920 |
| Volume: | 127 |
| Issue: | 3 |
| Pages: | 514 - 523 |
| DOI: | 10.1038/s41416-022-01822-6 |
| OADOI: | https://oadoi.org/10.1038/s41416-022-01822-6 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers |
| Subjects: | |
| Funding: |
This study was funded by Cancer Foundation Finland (59-5619 to JPV). SO’s effort was supported in part by a U.S. National Institutes of Health grant (R35 CA197735). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Open Access funding provided by University of Oulu including Oulu University Hospital. |
| Copyright information: |
© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |