University of Oulu

Tickner, Ben. J., & Zhivonitko, V. V. (2022). Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications. Chemical Science, 13(17), 4670–4696.

Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications

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Author: Tickner, Ben. J.1,2; Zhivonitko, Vladimir V.1
Organizations: 1NMR Research Unit, Faculty of Science, University of Oulu, P.O. Box 3000, Oulu, 90014, Finland
2Department of Chemical and Biological Physics, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, 7610001, Israel
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.8 MB)
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Language: English
Published: Royal Society of Chemistry, 2022
Publish Date: 2022-10-24


Parahydrogen-induced polarisation (PHIP) is a nuclear spin hyperpolarisation technique employed to enhance NMR signals for a wide range of molecules. This is achieved by exploiting the chemical reactions of parahydrogen (para-H₂), the spin-0 isomer of H₂. These reactions break the molecular symmetry of para-H₂ in a way that can produce dramatically enhanced NMR signals for reaction products, and are usually catalysed by a transition metal complex. In this review, we discuss recent advances in novel homogeneous catalysts that can produce hyperpolarised products upon reaction with para-H₂. We also discuss hyperpolarisation attained in reversible reactions (termed signal amplification by reversible exchange, SABRE) and focus on catalyst developments in recent years that have allowed hyperpolarisation of a wider range of target molecules. In particular, recent examples of novel ruthenium catalysts for trans and geminal hydrogenation, metal-free catalysts, iridium sulfoxide-containing SABRE systems, and cobalt complexes for PHIP and SABRE are reviewed. Advances in this catalysis have expanded the types of molecules amenable to hyperpolarisation using PHIP and SABRE, and their applications in NMR reaction monitoring, mechanistic elucidation, biomedical imaging, and many other areas, are increasing.

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Series: Chemical science
ISSN: 2041-6520
ISSN-E: 2041-6539
ISSN-L: 2041-6520
Volume: 13
Issue: 17
Pages: 4670 - 4696
DOI: 10.1039/d2sc00737a
Type of Publication: A2 Review article in a scientific journal
Field of Science: 116 Chemical sciences
Funding: VVZ acknowledges funding from the Academy of Finland (grant no. 323480), the European Research Council under Horizon 2020 (grant agreement no. 772110), and the University of Oulu (Kvantum Institute).
EU Grant Number: (772110) UFLNMR - Ultrafast Laplace NMR
Academy of Finland Grant Number: 323480
Detailed Information: 323480 (Academy of Finland Funding decision)
Copyright information: © 2022 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.