University of Oulu

Ullah, M. S., Mankinen, O., Zhivonitko, V. V., & Telkki, V.-V. (2022). Ultrafast transverse relaxation exchange NMR spectroscopy. Physical Chemistry Chemical Physics, 24(36), 22109–22114.

Ultrafast transverse relaxation exchange NMR spectroscopy

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Author: Ullah, Md Sharif1; Mankinen, Otto1; Zhivonitko, Vladimir V.1;
Organizations: 1NMR Research Unit, Faculty of Science, University of Oulu, P.O.Box 3000, 90014 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Royal Society of Chemistry, 2022
Publish Date: 2022-10-24


Molecular exchange between different physical or chemical environments occurs due to either diffusion or chemical transformation. Nuclear magnetic resonance (NMR) spectroscopy provides a means of understanding the molecular exchange in a noninvasive way and without tracers. Here, we introduce a novel two dimensional, single-scan ultrafast Laplace NMR (UF LNMR) method to monitor molecular exchange using transverse relaxation as a contrast. The UF T₂T₂ relaxation exchange spectroscopy (REXSY) method shortens the experiment time by one to two orders of magnitude compared to its conventional counterpart. Contrary to the conventional EXSY, the exchanging sites are distinguished based on T₂ relaxation times instead of chemical shifts, making the method especially useful for systems including physical exchange of molecules. Therefore, the UF REXSY method offers an efficient means for quantification of exchange processes in various fields such as cellular metabolism and ion transport in electrolytes. As a proof of principle, we studied a halogen-free orthoborate based ionic liquid system and followed molecular exchange between molecular aggregates and free molecules. The results are in good agreement with the conventional exchange studies. Due to the single-scan nature, the method potentially significantly facilitates the use of modern hyperpolarization techniques to boost the sensitivity by several orders of magnitude.

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Series: PCCP. Physical chemistry chemical physics
ISSN: 1463-9076
ISSN-E: 1463-9084
ISSN-L: 1463-9076
Volume: 24
Issue: 36
Pages: 22109 - 22114
DOI: 10.1039/d2cp02944h
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Funding: Financial support from the European Research Council (Project number 772110), Academy of Finland (Grant No. 323480 and 340099), KAUTE foundation and the University of Oulu (Kvantum Institute) is gratefully acknowledged. This work was carried out with the support of the Centre for Material Analysis, University of Oulu, Finland. We also acknowledge the research group of Oleg N. Antzutkin (Luleå University of Technology, Sweden) for providing the ionic liquid sample.
EU Grant Number: (772110) UFLNMR - Ultrafast Laplace NMR
Academy of Finland Grant Number: 323480
Detailed Information: 323480 (Academy of Finland Funding decision)
340099 (Academy of Finland Funding decision)
Copyright information: © the Owner Societies 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.