The standard point-of-care Hemochron Jr. ACT+ test in monitoring heparin administration for cardiopulmonary bypass in severe factor XII deficiency |
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Author: | Erkinaro, Tiina1; Moilanen, Janne1; Lahtinen, Jarmo1; |
Organizations: |
1Research Group of Surgery, Anesthesiology and Intensive Care Medicine, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Finland 2Nordlab Oulu Hematology Laboratory, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Finland |
Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 0.4 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe2022102763551 |
Language: | English |
Published: |
Elsevier,
2022
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Publish Date: | 2022-10-27 |
Description: |
AbstractCoagulation factor XII (FXII) is a plasma serine protease that belongs to the contact activation complex responsible for initiating the intrinsic coagulation pathway. FXII deficiency is a rare congenital disorder that is not associated with an increased tendency for bleeding. However, as contact activation is impaired in FXII deficiency, both the celite- and kaolin-initiated activated clotting time (ACT) measurements are prolonged markedly, which poses a challenge for anticoagulation monitoring in patients undergoing cardiac surgery. The authors successfully have used the standard Hemochron Jr. ACT+ test, which is activated by silica and phospholipid in addition to kaolin, to monitor anticoagulation for cardiopulmonary bypass in two patients with severe FXII deficiency. The ACT+ test showed low baseline values, increased adequately in response to heparin, and decreased to baseline after protamine. Importantly, there was no abnormal intra- or postoperative bleeding nor any thrombotic complications. Furthermore, in vitro dose-response ACT+ testing of FXII-deficient blood with increasing heparin concentrations supports the use of ACT+ in FXII deficiency. see all
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Series: |
Journal of cardiothoracic and vascular anesthesia |
ISSN: | 1053-0770 |
ISSN-E: | 1532-8422 |
ISSN-L: | 1053-0770 |
Volume: | 36 |
Issue: | 7 |
Pages: | 2031 - 2034 |
DOI: | 10.1053/j.jvca.2021.05.021 |
OADOI: | https://oadoi.org/10.1053/j.jvca.2021.05.021 |
Type of Publication: |
A1 Journal article – refereed |
Field of Science: |
3126 Surgery, anesthesiology, intensive care, radiology |
Subjects: | |
Copyright information: |
© 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |