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The incidence, hospitalisations and deaths in acutely ill children with dysnatraemias |
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| Author: | Lehtiranta, Saara1,2; Honkila, Minna1,2; Anttila, Silja2; |
| Organizations: |
1Department of Paediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland 2PEDEGO (Paediatrics, Dermatology, Gynecology, Obstetrics) Research Unit and Medical Research Centre Oulu, University of Oulu, Oulu, Finland 3Biocenter Oulu, University of Oulu, Oulu, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022110264381 |
| Language: | English |
| Published: |
John Wiley & Sons,
2022
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| Publish Date: | 2022-11-02 |
| Description: |
AbstractAim: The aim was to evaluate the incidence, hospitalisations and deaths in acutely ill children with dysnatraemias. Methods: This was a register-based cohort study of 46 518 acutely ill children aged <16 years who visited a paediatric emergency department. Risk factors were assessed using two nested case–control studies. Results: Moderate to severe hypernatraemia occurred in 92 children (0.20%; 95% confidence interval [CI]: 0.16%–0.24%) and moderate to severe hyponatraemia in 131 children (0.28%; 95% CI: 0.24%–0.33%). Underlying medical conditions increased the risk of both moderate to severe hypernatraemia (odds ratio [OR]: 17; 95% 5.5–51) and moderate to severe hyponatraemia (OR: 3.5; 95% CI: 2.0–5.9). The use of a feeding tube (OR: 14; 95% CI: 3.2–66) and intellectual disability (OR: 7.3; 95% CI: 3.0–18) was associated with moderate to severe hypernatraemia. The risk of death was associated with moderate to severe hypernatraemia (OR: 19; 95% CI: 2.0–2564) and moderate to severe hyponatraemia (OR: 33; 95% CI: 3.7–4311). Conclusions: Severe dysnatraemias were more prevalent in acutely ill children with underlying medical conditions and were markedly associated with the risk for death. see all
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| Series: |
Acta pædiatrica |
| ISSN: | 0803-5253 |
| ISSN-E: | 1651-2227 |
| ISSN-L: | 0803-5253 |
| Volume: | 111 |
| Issue: | 8 |
| Pages: | 1630 - 1637 |
| DOI: | 10.1111/apa.16348 |
| OADOI: | https://oadoi.org/10.1111/apa.16348 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
The study was supported by the Alma and K A Snellman Foundation, Finland (Saara Lehtiranta); the Foundation for Paediatric Research, Finland (Saara Lehtiranta, Minna Honkila, Terhi Tapiainen) and the Academy of Finland (Terhi Tapiainen) |
| Copyright information: |
© 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
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https://creativecommons.org/licenses/by/4.0/ |