University of Oulu

Salonen, J., Kreus, M., Lehtonen, S. et al. Decline in Mast Cell Density During Diffuse Alveolar Damage in Idiopathic Pulmonary Fibrosis. Inflammation 45, 768–779 (2022).

Decline in mast cell density during diffuse alveolar damage in idiopathic pulmonary fibrosis

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Author: Salonen, Johanna1,2; Kreus, Mervi1,1; Lehtonen, Siri2,3;
Organizations: 1Respiratory Medicine, Research Unit of Internal Medicine, University of Oulu, P.O. Box 8000, 90014, Oulu, Finland
2Medical Research Center (MRC) Oulu, Oulu University Hospital, P.O. Box 20, 90029 OYS, Oulu, Finland
3Department of Obstetrics and Gynecology, PEDEGO Research Unit, Oulu University Hospital, University Hospital of Oulu, P.O. Box 23, 90029 OYS, Oulu, Finland
4Infrastructure for Population Studies, Faculty of Medicine, Northern Finland Birth Cohorts, University of Oulu, Arctic Biobank, P.O. Box 8000, 90014, Oulu, Finland
5The Center of Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, P.O. Box 100, 70029 KYS, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
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Language: English
Published: Springer Nature, 2021
Publish Date: 2022-11-28


Mast cells (MCs) are known to be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF), although their role in acute exacerbations of IPF has not been investigated. The aims of the study were to evaluate the numbers of MCs in fibrotic and non-fibrotic areas of lung tissue specimens of idiopathic pulmonary fibrosis (IPF) patients with or without an acute exacerbation of IPF, and to correlate the MC density with clinical parameters. MCs of IPF patients were quantified from surgical lung biopsy (SLB) specimens (n = 47) and lung tissue specimens taken at autopsy (n = 7). MC density was higher in the fibrotic areas of lung tissue compared with spared alveolar areas or in controls. Female gender, low diffusion capacity for carbon monoxide, diffuse alveolar damage, and smoking were associated with a low MC density. MC densities of fibrotic areas had declined significantly in five subjects in whom both SLB in the stable phase and autopsy after an acute exacerbation of IPF had been performed. There were no correlations of MC densities with survival time or future acute exacerbations. The MC density in fibrotic areas was associated with several clinical parameters. An acute exacerbation of IPF was associated with a significant decline in MC counts. Further investigations will be needed to clarify the role of these cells in IPF and in the pathogenesis of acute exacerbation as this may help to identify some potential targets for medical treatment for this serious disease.

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Series: Inflammation
ISSN: 0360-3997
ISSN-E: 1573-2576
ISSN-L: 0360-3997
Volume: 45
Issue: 2
Pages: 768 - 779
DOI: 10.1007/s10753-021-01582-0
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: This work was supported by the Foundation of the Finnish Anti-Tuberculosis Association, Ryttylä, Finland; Research Foundation of the Pulmonary Diseases HES, Helsinki, Finland; Jalmari and Rauha Ahokas Foundation, Helsinki, Finland; Väinö and Laina Kivi Foundation, Helsinki, Finland; Tampere Tuberculosis Foundation, Tampere, Finland; and the Research Foundation of North Finland, Oulu, Finland. Open Access funding provided by University of Oulu including Oulu University Hospital.
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