Kujanpää, L., Arffman, R. K., Pesonen, P., Korhonen, E., Karjula, S., Järvelin, M., Franks, S., Tapanainen, J. S., Morin‐Papunen, L., & Piltonen, T. T. (2022). Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study. Acta Obstetricia et Gynecologica Scandinavica, 101(7), 728–736. https://doi.org/10.1111/aogs.14382
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age : a population-based cohort study
|Author:||Kujanpää, Linda1,2,3; Arffman, Riikka K.1,2,3; Pesonen, Paula4;|
1PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland
2Medical Research Center Oulu (MRC Oulu), University of Oulu, Oulu, Finland
3Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
4Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
5Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK
6Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
7Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland
8Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK
9Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
10Department of Obstetrics and Gynecology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2022120769812
John Wiley & Sons,
|Publish Date:|| 2022-12-07
Introduction: This population-based follow-up study investigated the comorbidities, medication use, and healthcare services among women with polycystic ovary syndrome (PCOS) at age 46 years.
Material and methods: The study population derived from the Northern Finland Birth Cohort 1966 and consisted of women reporting oligo/amenorrhea and hirsutism at age 31 years and/or a PCOS diagnosis by age 46 years (n = 246) and controls without PCOS symptoms or diagnosis (n = 1573), referred to as non-PCOS women. The main outcome measures were self-reported data on symptoms, diagnosed diseases, and medication and healthcare service use at the age of 46 years.
Results: Overall morbidity risk was increased by 35% (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.16–1.57) and medication use by 27% [RR 1.27, 95% CI 1.08–1.50) compared with non-PCOS women, and the risk remained after adjusting for body mass index. Diagnoses with increased prevalence in women with PCOS were migraine, hypertension, tendinitis, osteoarthritis, fractures, and endometriosis. PCOS was also associated with autoimmune diseases and recurrent upper respiratory tract infections and symptoms. Interestingly, healthcare service use did not differ between the study groups after adjusting for body mass index.
Conclusions: Women with PCOS are burdened with multimorbidity and higher medication use, independent of body mass index.
Acta obstetricia et gynecologica Scandinavica
|Pages:||728 - 736|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
This study was supported by grants from The Finnish Medical Foundation, The Academy of Finland (315921, 321763), The Sigrid Juselius Foundation, The Finnish Cultural Foundation, The Jalmari and Rauha Ahokas Foundation, The Päivikki and Sakari Sohlberg Foundation, Genesis Research Trust (UK), The Medical Research Council, UK (G0802782), University of Oulu (65354, 24301140), Oulu University Hospital (2/97, 8/97, 24302240), Ministry of Health and Social Affairs (23/251/97, 160/97, 190/97), National Institute for Health and Welfare (54121), Regional Institute of Occupational Health, (50621, 54231), and ERDF European Regional Development Fund (539/2010 A31592).
|Academy of Finland Grant Number:||
321763 (Academy of Finland Funding decision)
© 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.