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Anastasopoulou, S., Harila‐Saari, A., Als‐Nielsen, B., Eriksson, M. A., Heyman, M., Johannsdottir, I. M., Marquart, H. V., Niinimäki, R., Pronk, C. J., Schmiegelow, K., Vaitkeviciene, G., Thastrup, M., & Ranta, S. (2022). Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity? Pediatric Blood & Cancer, 69(7). https://doi.org/10.1002/pbc.29745

Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?

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Author: Anastasopoulou, Stavroula1,2; Harila-Saari, Arja3; Als-Nielsen, Bodil4;
Organizations: 1Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
2Department of Women's and Children's Health, Childhood Cancer Research Unit, Karolinska Institutet, Stockholm, Sweden
3Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
4Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark
5Department of Women's and Children's Health, Neuropediatric Unit, Karolinska Institutet, Stockholm, Sweden
6Department of Pediatric Hematology/Oncology, Oslo University Hospital, Oslo, Norway
7Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
8Department of Children and Adolescents, Oulu University Hospital and University of Oulu, PEDEGO Research Unit, Oulu, Finland
9Childhood Cancer Centre, Skåne University Hospital, Lund, Sweden
10Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark
11Children's Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos and Vilnius University, Vilnius, Lithuania
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022123074131
Language: English
Published: John Wiley & Sons, 2022
Publish Date: 2022-12-30
Description:

Abstract

Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) implicates enhanced intrathecal chemotherapy, which is related to CNS toxicity. Whether CNS involvement alone contributes to CNS toxicity remains unclear. We studied the occurrence of all CNS toxicities, seizures, and posterior reversible encephalopathy syndrome (PRES) in children with ALL without enhanced intrathecal chemotherapy with CNS involvement (n = 64) or without CNS involvement (n = 256) by flow cytometry. CNS involvement increased the risk for all CNS toxicities, seizures, and PRES in univariate analysis and, after adjusting for induction therapy, for seizures (hazard ratio [HR] = 3.33; 95% confidence interval [CI]: 1.26–8.82; p = 0.016) and PRES (HR = 4.85; 95% CI: 1.71–13.75; p = 0.003).

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Series: Pediatric blood & cancer
ISSN: 1545-5009
ISSN-E: 1545-5017
ISSN-L: 1545-5009
Volume: 69
Issue: 7
Article number: e29745
DOI: 10.1002/pbc.29745
OADOI: https://oadoi.org/10.1002/pbc.29745
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
3123 Gynaecology and paediatrics
Subjects:
CNS leukemia
CNS toxicity
flow cytometric immunophenotyping
pediatric acute lymphoblastic leukemia
Article
Funding: This study was supported by grants provided by the Swedish Childhood Cancer Fund, Sweden.
Copyright information: © 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
  https://creativecommons.org/licenses/by-nc-nd/4.0/