University of Oulu

Chen, Y.-M., Zang, L.-S., Koc-Bilican, B., Bilican, I., Holland, C., Cansaran-Duman, D., Karaduman, T., Çolak, A., Bayır, Y., Halici, Z., Ozmen, S., Ali, A., Labidi, J., Elbuken, C., & Kaya, M. (2022). Macroporous surgical mesh from a natural cocoon composite. ACS Sustainable Chemistry & Engineering, 10(18), 5728–5738.

Macroporous surgical mesh from a natural cocoon composite

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Author: Chen, Yong-Ming1; Zang, Lian-Sheng1; Koc-Bilican, Behlul2,3;
Organizations: 1Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, 550025 Guiyang, China
2Department of Biotechnology, Faculty of Science and Letters, Aksaray University, 68100 Aksaray, Turkey
3ASUBTAM-Science and Technology Application and Research Center, Aksaray University, 68100 Aksaray, Turkey
4Department of Electronics and Automation, Technical Vocational School, Aksaray University, 68100 Aksaray, Turkey
5Department of Materials Science and Engineering, University of Sheffield, Mappin Street, S1 3JD Sheffield, U.K.
6Institute of Biotechnology, Ankara University, 06110 Ankara, Turkey
7Department of Physics, Faculty of Arts and Sciences, Clarkson University, 13699 New York, New York, United States
8Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey
9Department of Medical Pharmacology, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey
10Department of Pathology, Ataturk University Faculty of Medicine, 25240 Erzurum, Turkey
11Department of Agriculture, Abdul Wali Khan University, Mardan 23200 Khyber Pakhtunkhwa, Pakistan
12Biorefinery Processes Research Group, Department of Chemical and Environmental Engineering, University of the Basque Country (UPV/EHU), Plaza Europa 1, 20018 Donostia-San Sebastian, Spain
13UNAM─National Nanotechnology Research Center, Institute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, Turkey
14Faculty of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 2.1 MB)
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Language: English
Published: American Chemical Society, 2022
Publish Date: 2023-01-23


Recently, traditional polymer-based surgical meshes have drawn unwanted attention as a result of host tissue complications arising from infection, biocompatibility, and mechanical compatibility. Seeking an alternative solution, we present a hierarchically structured nanofibrous surgical mesh derived from the naturally woven cocoon of the Japanese giant silkworm, termed MothMesh. We report that it displays nontoxicity, biocompatibility, suitable mechanical properties, and porosity while showing no adverse effect in animal trials and even appears to enhance cell proliferation. Hence, we assert that the use of this natural material may provide an effective and improved alternative to existing synthetic meshes.

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Series: ACS sustainable chemistry & engineering
ISSN: 2168-0485
ISSN-E: 2168-0485
ISSN-L: 2168-0485
Volume: 10
Issue: 18
Pages: 5728 - 5738
DOI: 10.1021/acssuschemeng.1c06941
Type of Publication: A1 Journal article – refereed
Field of Science: 116 Chemical sciences
Funding: This study was funded by the Program of Introducing Talents to Chinese Universities (111 Program, D20023). The authors thanks the ASUBTAM (Aksaray University) for providing laboratory facilities and access to equipment.
Copyright information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry & Engineering, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see