University of Oulu

Mahmud, Md. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, Md. R., Acharjee, M., Hossain, Md. S., & Pirttilä, A. M. (2022). Impact of gut microbiome on skin health: Gut-skin axis observed through the lenses of therapeutics and skin diseases. Gut Microbes, 14(1), 2096995.

Impact of gut microbiome on skin health : gut-skin axis observed through the lenses of therapeutics and skin diseases

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Author: Mahmud, Md. Rayhan1; Akter, Sharmin2; Tamanna, Sanjida Khanam2;
Organizations: 1Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
2Department of Microbiology, Jagannath University, Dhaka, Bangladesh
3Department of Bioscience, Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan
4Institute of Biology, Eötvös Loránd University, Budapest, Hungary
5Ecology and Genetics, Faculty of Science, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 5.4 MB)
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Language: English
Published: Informa, 2022
Publish Date: 2023-01-27


The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and the immune system is impaired, subsequent effects can be triggered on the skin, potentially promoting the development of skin diseases. The mechanisms through which the gut microbiome affects skin health are still unclear. Enhancing our understanding on the connection between skin and gut microbiome is needed to find novel ways to treat human skin disorders. In this review, we systematically evaluate current data regarding microbial ecology of healthy skin and gut, diet, pre- and probiotics, and antibiotics, on gut microbiome and their effects on skin health. We discuss potential mechanisms of the gut-skin axis and the link between the gut and skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. This review will increase our understanding of the impacts of gut microbiome on skin conditions to aid in finding new medications for skin-associated diseases.

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Series: Gut microbes
ISSN: 1949-0976
ISSN-E: 1949-0984
ISSN-L: 1949-0976
Volume: 14
Issue: 1
Article number: e2096995
DOI: 10.1080/19490976.2022.2096995
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: Open access to this publication is funded by Helsinki University Library.
Copyright information: © 2022 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.