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Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases |
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| Author: | Mononen, Minna1,2; Saari, Eeva1,2; Hasala, Hannele3; |
| Organizations: |
1Division of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland 2Center of Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland 3Department of Respiratory Medicine, Tampere University Hospital, POB 2000, 33521, Tampere, Finland
4Department of Clinical Radiology, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland
5Institute of Clinical Radiology, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland 6Acute Services, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland 7Science Services Center, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland 8Tampere University Heart Hospital and Finnish Cardiovascular Research Center, Tampere University, 33014, Tampere, Finland 9Research Unit of Internal Medicine, University of Oulu, POB 500, 90400, Oulu, Finland 10Center of Internal Medicine and Respiratory Medicine and Medical Research Center (MRC) Oulu, Oulu University Hospital, POB 20, 90029 OYS, Oulu, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.2 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023020325665 |
| Language: | English |
| Published: |
Springer Nature,
2022
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| Publish Date: | 2023-02-03 |
| Description: |
AbstractBackground: The disease course of idiopathic pulmonary fibrosis (IPF) is progressive and occasionally, other types of interstitial lung disease (ILD) may progress similarly to IPF. This study aimed to evaluate risk factors for disease progression within 24 months in patients with various ILDs. Methods: This prospective study obtained 97 patients with a suspected ILD who underwent a transbronchial lung cryobiopsy. The extent of several high-resolution computed tomography (HRCT) patterns was assessed. Due to the inclusion criteria the study population presented a low extent of honeycombing and definite usual interstitial pneumonia (UIP) pattern on HRCT suggesting an early stage of ILD. Disease progression within 24 months despite treatment was defined as a relative decline of ≥ 10% in forced vital capacity (FVC), or a relative decline in FVC of ≥ 5% and one of the three additional criteria: (1) a decline in diffusion capacity to carbon monoxide (DLCO) ≥ 15%; (2) increased fibrosis on HRCT; (3) progressive symptoms, or progressive symptoms and increased fibrosis on HRCT. The same definition was utilized in patients with IPF and other ILDs. Risk factors for disease progression were evaluated in a multivariable logistic regression model. Results: Disease progression was revealed in 52% of the patients with ILD, 51% of the patients with IPF, and 53% of the patients with other types of ILD. A high extent of reticulation on HRCT (Odds ratio [OR] 3.11, 95% Confidence interval [CI] 1.21–7.98, P = 0.019) and never smoking (OR 3.11, CI 1.12–8.63, P = 0.029) were associated with disease progression whereas platelet count (OR 2.06 per 100 units increase, CI 0.96–4.45, P = 0.065) did not quite reach statistical significance. Conclusion: Higher extent of reticulation on HRCT and never smoking appeared to associate with the risk of disease progression within 24 months in ILD patients without honeycombing. Approximately half of the patients with ILD revealed disease progression, and similar proportions were observed in patients with IPF and in other types of ILD. see all
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| Series: |
BMC pulmonary medicine |
| ISSN: | 1471-2466 |
| ISSN-E: | 1471-2466 |
| ISSN-L: | 1471-2466 |
| Volume: | 22 |
| Article number: | 313 |
| DOI: | 10.1186/s12890-022-02105-9 |
| OADOI: | https://oadoi.org/10.1186/s12890-022-02105-9 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
This study was supported by the Foundation of the Finnish Anti-Tuberculosis Association, Väinö and Laina Kivi Foundation, The Research Foundation of the Pulmonary Diseases, Jalmari and Rauha Ahokas Foundation, and The Respiratory Foundation of the Kuopio Region. The funding had no role in the design of the study neither in collection, analysis, and interpretation of data or writing the manuscript. |
| Copyright information: |
© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://creativecommons.org/licenses/by/4.0/ |