Mononen, M., Saari, E., Hasala, H. et al. Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases. BMC Pulm Med 22, 313 (2022). https://doi.org/10.1186/s12890-022-02105-9
Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases
|Author:||Mononen, Minna1,2; Saari, Eeva1,2; Hasala, Hannele3;|
1Division of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland
2Center of Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland
3Department of Respiratory Medicine, Tampere University Hospital, POB 2000, 33521, Tampere, Finland
4Department of Clinical Radiology, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland
5Institute of Clinical Radiology, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland
6Acute Services, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland
7Science Services Center, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland
8Tampere University Heart Hospital and Finnish Cardiovascular Research Center, Tampere University, 33014, Tampere, Finland
9Research Unit of Internal Medicine, University of Oulu, POB 500, 90400, Oulu, Finland
10Center of Internal Medicine and Respiratory Medicine and Medical Research Center (MRC) Oulu, Oulu University Hospital, POB 20, 90029 OYS, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 1.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023020325665
|Publish Date:|| 2023-02-03
Background: The disease course of idiopathic pulmonary fibrosis (IPF) is progressive and occasionally, other types of interstitial lung disease (ILD) may progress similarly to IPF. This study aimed to evaluate risk factors for disease progression within 24 months in patients with various ILDs.
Methods: This prospective study obtained 97 patients with a suspected ILD who underwent a transbronchial lung cryobiopsy. The extent of several high-resolution computed tomography (HRCT) patterns was assessed. Due to the inclusion criteria the study population presented a low extent of honeycombing and definite usual interstitial pneumonia (UIP) pattern on HRCT suggesting an early stage of ILD. Disease progression within 24 months despite treatment was defined as a relative decline of ≥ 10% in forced vital capacity (FVC), or a relative decline in FVC of ≥ 5% and one of the three additional criteria: (1) a decline in diffusion capacity to carbon monoxide (DLCO) ≥ 15%; (2) increased fibrosis on HRCT; (3) progressive symptoms, or progressive symptoms and increased fibrosis on HRCT. The same definition was utilized in patients with IPF and other ILDs. Risk factors for disease progression were evaluated in a multivariable logistic regression model.
Results: Disease progression was revealed in 52% of the patients with ILD, 51% of the patients with IPF, and 53% of the patients with other types of ILD. A high extent of reticulation on HRCT (Odds ratio [OR] 3.11, 95% Confidence interval [CI] 1.21–7.98, P = 0.019) and never smoking (OR 3.11, CI 1.12–8.63, P = 0.029) were associated with disease progression whereas platelet count (OR 2.06 per 100 units increase, CI 0.96–4.45, P = 0.065) did not quite reach statistical significance.
Conclusion: Higher extent of reticulation on HRCT and never smoking appeared to associate with the risk of disease progression within 24 months in ILD patients without honeycombing. Approximately half of the patients with ILD revealed disease progression, and similar proportions were observed in patients with IPF and in other types of ILD.
BMC pulmonary medicine
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
This study was supported by the Foundation of the Finnish Anti-Tuberculosis Association, Väinö and Laina Kivi Foundation, The Research Foundation of the Pulmonary Diseases, Jalmari and Rauha Ahokas Foundation, and The Respiratory Foundation of the Kuopio Region. The funding had no role in the design of the study neither in collection, analysis, and interpretation of data or writing the manuscript.
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