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Substance use confounds associations between peer victimization and aggression in adolescence with mental disorders in adulthood : a prospective birth cohort study |
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| Author: | Sarala, Marian1; Miettunen, Jouko2,3; Alakokkare, Anni-Emilia2,4; |
| Organizations: |
1Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland 2Center for Life Course Health Research, University of Oulu, Oulu, Finland 3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Department of Psychiatry, University of Turku, Turku, Finland
5Faculty of Medicine and Health Technology, University Consortium of Seinäjoki, Tampere University, Tampere, Finland 6QIMR Berghofer Medical Institute, Herston, Queensland, Australia 7Metro North Mental Health, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia 8Queensland Centre for Mental Health Research, Wacol, Queensland, Australia 9School of Public Health, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia 10PEDEGO Research Unit, Child Psychiatry, University of Oulu, Oulu, Finland 11Clinic of Child Psychiatry, Oulu University Hospital, Oulu, Finland 12Department of Psychiatry, Addiction Psychiatry Unit, Hospital District of South-West Finland, Turku, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | embargoed |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023020325727 |
| Language: | English |
| Published: |
John Wiley & Sons,
2022
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| Publish Date: | 2023-07-26 |
| Description: |
AbstractIntroduction: Peer victimization and aggression in adolescence are associated with later mental health morbidity. However, studies examining this association have not controlled for adolescent substance use. We aimed to study the associations between peer victimization, peer aggression, and mental disorders in adulthood, adjusting for substance use in adolescence. Methods: Participants were from the prospective Northern Finland Birth Cohort 1986. Data were available for 6682 individuals (70.8% of the original sample). Peer victimization and peer aggression were assessed with items from the Achenbach Youth Self Report at ages 15−16 years. Outcomes were nonorganic psychosis, anxiety disorder, mood disorder, substance use disorder, and any mental disorder (a none-vs-any indicator) at age 33 years collected from nationwide health care, insurance, and pension registers. Family structure, alcohol intoxication frequency, daily smoking, illicit drug use, and baseline psychopathology using Youth Self-Report total score, and parental mental disorders were considered as confounding factors. Results: In multivariable analyses, the association between peer victimization and psychosis (Hazard ratio [HR]: 2.9, 95% confidence interval [CI]: 1.2−6.9, p = .020) and mood disorder (HR: 1.7, 95% CI: 1.2−2.4, p = .012) in females remained significant after adjusting for confounders. Other associations between female and male peer victimization or aggression and the studied outcomes attenuated after adjustments. Conclusions: Some associations between peer victimization and aggression and later mental health morbidity are explained by adolescent substance use. For females, substance use does not account for the increased risk of psychosis and mood disorder in those who experience peer victimization. see all
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| Series: |
Journal of adolescence |
| ISSN: | 0140-1971 |
| ISSN-E: | 1095-9254 |
| ISSN-L: | 0140-1971 |
| Volume: | 94 |
| Issue: | 7 |
| Pages: | 996 - 1007 |
| DOI: | 10.1002/jad.12080 |
| OADOI: | https://oadoi.org/10.1002/jad.12080 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3124 Neurology and psychiatry |
| Subjects: | |
| Funding: |
This work was financially supported by EU QLG1-CT-2000-01643 (EUROBLCS) Grant no. E51560, NorFA Grant no. 731, 20056, 30167, USA/NIH 2000 G DF682 Grant no. 50945, Juho Vainio foundation, and the Sohlberg foundation. |
| Copyright information: |
© 2022 The Foundation for Professionals in Services for Adolescents. This is the peer reviewed version of the following article: Sarala, M., Miettunen, J., Alakokkare, A.-E., Mustonen, A., Scott, J. G., Thomas, H. J., Hurtig, T., & Niemelä, S. (2022). Substance use confounds associations between peer victimization and aggression in adolescence with mental disorders in adulthood: A prospective birth cohort study. Journal of Adolescence, 94, 996– 1007., which has been published in final form at https://doi.org/10.1002/jad.12080. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |