University of Oulu

Marttinen, M., Oura, P., Huttunen, M., Vartiainen, P., & Paananen, M. (2022). Determinants of responsiveness to multidisciplinary chronic pain management interventions: Protocol for a systematic review and meta-analysis. BMJ Open, 12(9), e057481.

Determinants of responsiveness to multidisciplinary chronic pain management interventions : protocol for a systematic review and meta-analysis

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Author: Marttinen, Maiju1; Oura, Petteri2,3; Huttunen, Merja4;
Organizations: 1The Finnish Center for Pediatric and Adolescent Pain Management and Research, New Children’s Hospital, Helsinki University Hospital, Helsinki University Central Hospital, Helsinki, Finland
2Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
3Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
4Department of Anesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital, Helsinki, Finland
5Department of Paediatrics, Päijät-Häme Central Hospital, Lahti, Finland
6City of Espoo Health Services, Espoo, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
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Language: English
Published: BMJ, 2022
Publish Date: 2023-02-06


Introduction: The current manuscript presents a protocol for a systematic review and meta-analysis of the evidence regarding the determinants of responsiveness to multidisciplinary management of chronic pain, with pain intensity, pain-related interference, physical functioning and health-related quality of life as the main outcomes, with consideration to multiple secondary outcomes.

Methods and analysis: To identify relevant studies, the Ovid MEDLINE, PubMed, Ovid PsycINFO, EBSCO CINAHL and Scopus databases will be searched for all studies exploring factors associated with responsiveness to multidisciplinary pain management from study inception to the present. Cohorts, case–control studies and randomised controlled trials will be included. Independent screening for eligible studies will be completed by a total of four researchers using defined criteria. Data extraction will be executed by two researchers. Study heterogeneity will be estimated using the I2 index. A meta-analysis will be performed using random effects models. Publication bias will be evaluated by means of funnel plots and Egger’s test.

Ethics and dissemination: The proposed study does not involve collection of primary data. Therefore, no ethical approval is required. The results of the systematic review and meta-analysis will be presented in a peer-reviewed journal and at conferences.

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Series: BMJ open
ISSN: 2044-6055
ISSN-E: 2044-6055
ISSN-L: 2044-6055
Volume: 12
Issue: 9
Article number: e057481
DOI: 10.1136/bmjopen-2021-057481
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Copyright information: © Author(s) (or their employer(s)) 2022. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: