University of Oulu

Soppela, H., Katisko, K., Gadola, Y., Krüger, J., Hartikainen, P., Alberici, A., Benussi, A., Koivisto, A., Haapasalo, A., Remes, A. M., Borroni, B., & Solje, E. (2022). Modifiable potential risk factors in familial and sporadic frontotemporal dementia. Annals of Clinical and Translational Neurology, 9(8), 1195–1205.

Modifiable potential risk factors in familial and sporadic frontotemporal dementia

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Author: Soppela, Helmi1; Katisko, Kasper1; Gadola, Yasmine2;
Organizations: 1Institute of Clinical Medicine – Neurology, University of Eastern Finland, Kuopio, Finland
2Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
3Research Unit of Clinical Neuroscience – Neurology, University of Oulu, Oulu, Finland
4MRC – Oulu University Hospital, Oulu, Finland
5Neuro Center – Neurology, Kuopio University Hospital, Kuopio, Finland
6Neurology Unit, ASST Spedali Civili Brescia, Brescia, Italy
7Neuro Center, Neurology, Helsinki University Hospital, Helsinki, Finland
8A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
Persistent link:
Language: English
Published: John Wiley & Sons, 2022
Publish Date: 2023-02-14


Objective: Only a few studies have evaluated modifiable risk factors for frontotemporal dementia (FTD). Here, we evaluated several modifiable factors and their association with disease phenotype, genotype, and prognosis in a large study population including Finnish and Italian patients with FTD and control groups.

Methods: In this case–control study, we compared the presence of several cardiovascular and other lifestyle-related diseases and education between Finnish and Italian patients with familial (n = 376) and sporadic (n = 654) FTD, between different phenotypes of FTD, and between a subgroup of Finnish FTD patients (n = 221) and matched Finnish patients with Alzheimer’s disease (AD) (n = 214) and cognitively healthy controls (HC) (n = 100).

Results: Patients with sporadic FTD were less educated (p = 0.042, B = -0.560, 95% CI −1.101 to −0.019) and had more heart diseases (p < 0.001, OR = 2.265, 95% CI 1.502–3.417) compared to patients with familial FTD. Finnish FTD patients were less educated (p = 0.032, B = 0.755, 95% CI 0.064–1.466) compared with AD patients. The Finnish FTD group showed lower prevalence of hypertension than the HC group (p = 0.003, OR = 2.162, 95% CI 1.304–3.583) and lower prevalence of hypercholesterolemia than in the HC group (p < 0.001, OR = 2.648, 95%CI 1.548–4.531) or in the AD group (p < 0.001, OR = 1.995, 95% CI 1.333–2.986). Within the FTD group, clinical phenotypes also differed regarding education and lifestyle-related factors.

Interpretation: Our study suggests distinct profiles of several modifiable factors in the FTD group depending on the phenotype and familial inheritance history and that especially sporadic FTD may be associated with modifiable risk factors.

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Series: Annals of clinical and translational neurology
ISSN: 2328-9503
ISSN-E: 2328-9503
ISSN-L: 2328-9503
Volume: 9
Issue: 8
Pages: 1195 - 1205
DOI: 10.1002/acn3.51619
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: This work was supported by the Academy of Finland (under grant numbers 315459, AH and 315460, AMR), Finnish Brain Foundation (ES, KK), Sigrid Juselius Foundation (ES, AH), Instrumentarium Science Foundation (ES), Orion Research Foundation (ES), and Finnish Medical Foundation (KK).
Academy of Finland Grant Number: 315460
Detailed Information: 315460 (Academy of Finland Funding decision)
Copyright information: © 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.