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Lomanovskaya, T. A., Piavchenko, G. A., Soldatov, V. O., Venediktov, A. A., Kuzmin, E. A., Kartashkina, N. L., Mukhamedova, S. G., Boronikhina, T. V., Markov, A. G., Telyshev, D. V., Meglinski, I., Yatskovskiy, A. N., J. Biophotonics 2023, 16( 1), e202200222. https://doi.org/10.1002/jbio.202200222

Structural changes of erythrocyte membrane revealed by 3D confocal optical profilometer

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Author: Lomanovskaya, Tatiana A.1; Piavchenko, Gennadii A.1; Soldatov, Vladislav O.2;
Organizations: 1Department of Histology, Cytology and Embryology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
2Pharmacology and Clinical Pharmacology Department, Belgorod National Research University, Belgorod, Russia
3Institute of Biomedical Systems, National Research University of Electronic Technology, Zelenograd, Moscow, Russia
4Opto-Electronics and Measurement Techniques, Faculty of Information and Electrical Engineering, University of Oulu, Oulu, Finland
5College of Engineering and Physical Sciences, Aston University, Birmingham, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 7.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2023021627519
Language: English
Published: John Wiley & Sons, 2023
Publish Date: 2023-02-16
Description:

Abstract

We examined hematological changes influenced by the experimental hypervitaminosis A. The 3D confocal optical profilometer was applied for assessment of the erythrocytes’ membrane structural changes influenced by an overdose of vitamin A. The blood smears were evaluated in terms of alterations of geometrical and optical parameters of erythrocytes for two groups of animals: oil base and retinol palmitate (n = 9 animals for each group). The results demonstrate that an overdose of retinol palmitate causes changes in the torus curvature and pallor of discocytes, their surface area and volume. The observed structural malformations of the shape of red blood cells become visible at the earlier preclinical stage of changes in animal state and behavior. With this in mind, the results of the study open a new area of research in the certain dysfunction diagnosis of red blood cells and have a great potential in the further development of new curative protocols.

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Series: Journal of biophotonics
ISSN: 1864-063X
ISSN-E: 1864-0648
ISSN-L: 1864-063X
Volume: 16
Issue: 1
Article number: e202200222
DOI: 10.1002/jbio.202200222
OADOI: https://oadoi.org/10.1002/jbio.202200222
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Subjects:
3D confocal optical profilometry
erythrocyte morphology
hypervitaminosis A
morphodensitometric traits
retinol palmitate
Article
Funding: Academy of Finland, Grant/Award Numbers: 325097, 351068; Leverhulme Trust and The Royal Society, Grant/Award Number: APX111232; The Ministry of Science and Higher Education of the Russian Federation, Grant/Award Number: 075-15-2022-304
Academy of Finland Grant Number: 325097
351068
Detailed Information: 325097 (Academy of Finland Funding decision)
351068 (Academy of Finland Funding decision)
Copyright information: © 2022 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
  https://creativecommons.org/licenses/by-nc-nd/4.0/