University of Oulu

Savukoski, Susanna M. MD1,2; Pinola, Pekka A. MD1,2; Pesonen, Paula R. O. MSc3; Puukka, Katri S. PhD2,4,5; Suvanto, Eila T. J. MD1,2; Niinimäki, Maarit J. MD1,2. Climacteric status is associated with sexual dysfunction at the age of 46 years: a population-based study. Menopause 29(11):p 1239-1246, November 2022. | DOI: 10.1097/GME.0000000000002054

Climacteric status is associated with sexual dysfunction at the age of 46 : a population-based study

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Author: Savukoski, Susanna M.1,2; Pinola, Pekka A.1,2; Pesonen, Paula R. O.3;
Organizations: 1Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, Finland
2Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
3Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
4NordLab Oulu, Oulu University Hospital, Oulu, Finland
5Department of Clinical Chemistry, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2023022728791
Language: English
Published: Wolters Kluwer, 2022
Publish Date: 2023-09-06
Description:

Abstract

Objectives: Increasing age and menopausal transition increase the risk of sexual dysfunction. Sexual dysfunction is common in women experiencing menopause before the age of 40 years, whereas evidence on sexual function in women experiencing menopause in their mid-40s is scarce. We aimed to investigate sexual function in 46-year-old women in relation to their menopausal status.

Methods: This study cross-sectionally evaluated sexual function of women in a prospective population-based Northern Finland Birth Cohort 1966 (NFBC1966). A 46-year follow-up study of NFBC1966 included a broad questionnaire evaluating health, lifestyle, and life situation, as well as menstrual history and sexual function, and blood sampling analysis including follicle stimulating hormone and free androgen index (FAI). The participants were divided into two groups by their menopause status, defined by follicle-stimulating hormone and menstrual history. We performed logistic regression models in which parameters of sexual function were dependent factors and climacteric status, self-reported health, FAI, relationship status, smoking, and education level were independent variables.

Results: The study population included 2,661 women. In regression models, more advanced climacteric status was associated with higher frequency and difficulty level of low sexual desire and vaginal dryness (odds ratios with 95% confidence intervals: 2.80 [2.12‐3.71], 3.22 [2.43‐4.27], 3.83 [2.82‐5.20], 3.75 [2.75‐5.12], respectively), lower frequency of sexual thoughts (1.34 [1.02‐1.75]), and higher frequency of problems with intercourse (2.35 [1.51‐3.66]). Lower FAI and poorer health were associated with impaired sexual function.

Conclusions: The current study suggests that women experiencing menopausal transition in their mid-40s are at risk of impaired sexual function.

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Series: Menopause
ISSN: 1072-3714
ISSN-E: 1530-0374
ISSN-L: 1072-3714
Volume: 29
Issue: 11
Pages: 1239 - 1246
DOI: 10.1097/GME.0000000000002054
OADOI: https://oadoi.org/10.1097/GME.0000000000002054
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Funding: Northern Finland Birth Cohort 1966 received financial support from University of Oulu Grant no. 24000692, Oulu University Hospital grant 24301140, ERDF European Regional Development Fund Grant no. 539/2010 A31592. Pekka Pinola, Paula Pesonen, Katri Puukka, Eila Suvanto and Maarit Niinimäki received no financial support for the research, authorship, and/or publication of this article. Susanna Savukoski received a research grant from the Finnish Menopause Society, Juho Vainio Foundation, and Finnish Medical Foundation.
Copyright information: © 2022 by The North American Menopause Society. This is a pre-copyedited, author-produced version of an article accepted for publication in Menopause. The published version of record Savukoski, Susanna M. MD1,2; Pinola, Pekka A. MD1,2; Pesonen, Paula R. O. MSc3; Puukka, Katri S. PhD2,4,5; Suvanto, Eila T. J. MD1,2; Niinimäki, Maarit J. MD1,2. Climacteric status is associated with sexual dysfunction at the age of 46 years: a population-based study. Menopause 29(11):p 1239-1246, November 2022. | DOI: 10.1097/GME.0000000000002054 is available online at: https://doi.org/10.1097/GME.0000000000002054.