|
|
Does climacteric status impact regulation of the autonomic nervous system at the age of 46 years? |
|---|---|
| Author: | Salin, Satu1,2; Savukoski, Susanna1,2; Tulppo, Mikko3; |
| Organizations: |
1Department of Obstetrics and Gynecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, OYS, Oulu, Finland 2Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland 3Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
4Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
5Centre for Life Course Health Research, University of Oulu, Oulu, Finland 6NordLab Oulu, Oulu University Hospital, Oulu, Finland 7Department of Clinical Chemistry, University of Oulu, Oulu, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | embargoed |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023030229171 |
| Language: | English |
| Published: |
Informa,
2022
|
| Publish Date: | 2023-04-06 |
| Description: |
AbstractObjectives: To investigate whether an earlier-onset climacteric phase is associated with autonomic imbalance at the age of 46 years. Methods: This cross-sectional birth cohort study included 2661 women aged 46 years. Participants were divided into climacteric (n = 359) and preclimacteric (n = 2302) groups based on menstrual history and follicle stimulating hormone values. The mean heart rate (HR), low-frequency (LF) power, high-frequency (HF) power and LF/HF ratio were analyzed from heart rate variability recordings. The variables were compared between the groups using multivariable linear regression models, including body mass index, smoking and physical activity. The effects of hormone therapy and hot flashes on autonomic function were evaluated in sub-analyses. Results: Climacteric women had a lower mean HR in seated (71.9 ± 10.5 vs. 72.6 ± 10.4 bpm, p = 0.015) and standing (81.2 ± 12.8 vs. 83.6 ± 12.1 bpm, p = 0.002) positions compared to preclimacteric women, and the differences remained significant after the adjustments. In the sub-analyses, more frequent hot flashes were associated with a lower LF power and LF/HF ratio in the sitting position. Conclusions: The present study suggested an association between greater parasympathetic activation in women with more advanced climacteric status at the age of 46 years. see all
|
| Series: |
Climacteric |
| ISSN: | 1369-7137 |
| ISSN-E: | 1473-0804 |
| ISSN-L: | 1369-7137 |
| Volume: | 25 |
| Issue: | 6 |
| Pages: | 586 - 594 |
| DOI: | 10.1080/13697137.2022.2052842 |
| OADOI: | https://oadoi.org/10.1080/13697137.2022.2052842 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
S. Salin, M. Tulppo, P. Pesonen, J. Auvinen, E. Suvanto, K. Puukka and M. Niinimäki received no financial support for the research, authorship and/or publication of this article. S. Savukoski received a grant from the Finnish Menopause Society; Finnish Medical Foundation; Juho Vainio Foundation. |
| Copyright information: |
This is an Accepted Manuscript version of the following article, accepted for publication in Climacteric. S. Salin, S. Savukoski, M. Tulppo, P. Pesonen, J. Auvinen, E. Suvanto, K. Puukka & M. Niinimäki (2022) Does climacteric status impact regulation of the autonomic nervous system at the age of 46 years?, Climacteric, 25:6, 586-594, DOI: 10.1080/13697137.2022.2052842 It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
|
https://creativecommons.org/licenses/by-nc/4.0/ |