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The long-term prognostic value of serum 25(OH)D, albumin, and LL-37 levels in acute respiratory diseases among older adults |
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| Author: | Aronen, Matti1,2; Viikari, Laura3; Langen, Henriikka1; |
| Organizations: |
1Department of Geriatrics, Turku University Hospital, Turku, Finland 2Uikunkuja 7, N28100, Pori, Finland 3Turku City Hospital, Turku, Finland
4Department of Radiology, Turku University Hospital, Turku, Finland
5Department of Medical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland 6Department of Virology, University of Helsinki, Helsinki, Finland 7Massachusetts General Hospital, Harvard Medical School, Boston, USA 8Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland 9PEDEGO Research Unit, Medical Research Center, University of Oulu, Oulu, Finland 10Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland 11Department of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.1 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023030630018 |
| Language: | English |
| Published: |
Springer Nature,
2022
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| Publish Date: | 2023-03-06 |
| Description: |
AbstractBackground: Older adults are more susceptible to respiratory tract infection than healthy working age adults. The increased susceptibility of older adults is thought to be interlinked with vitamin D status, nourishment, and immunological state in general. Data are scarce whether these parameters could serve as prognostic markers. Aim: To study whether serum 25(OH)D, albumin, and LL-37 level could give prognostic value of long-term survival in the older adults with multimorbidity and acute respiratory infection. Methods: Consecutive episodes of hospital care of patients 65 years and older with respiratory symptoms were prospectively studied as a cohort. Standard clinical questionnaire was filled by the study physician. Laboratory markers included serum levels of 25(OH)D, albumin and LL-37, C-reactive protein (CRP), white blood cell count (WBC) and polymerase chain reaction diagnostics for 14 respiratory viruses. Pneumonia was confirmed by chest radiographs. Respiratory illness severity, death at ward, length of hospital stays, and 5-year survival were used as outcomes. Results: In total, 289 older adult patients with mean age of 83 years were included in the study. Serum 25(OH)D deficiency (< 50 nmol/liter) was present in 59% and hypoalbuminemia (< 3.5 g/dL) in 55% of the study patients. Low serum albumin level was associated to one, two- and five-year mortality after hospital stay (all P <.05). In addition, it was associated with pneumonia, dyspnea, over 13-night long stay at ward and death at ward (all P < .05). No associations were seen between serum 25(OH)D and LL-37 levels and disease severity, short-term clinical outcome, or long-term survival. Associations between serum 25(OH)D, albumin, and LL-37 levels and respiratory virus presence were not seen. Conclusions: Serum albumin level on admission seems to give valuable information about the patients’ general health and recovery potential in treating older adults with respiratory symptoms. Serum 25(OH)D and LL-37 had no associations with disease severity or long- and short-term prognosis among older adults hospitalized with respiratory symptoms. see all
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| Series: |
BMC geriatrics |
| ISSN: | 1471-2318 |
| ISSN-E: | 1471-2318 |
| ISSN-L: | 1471-2318 |
| Volume: | 22 |
| Issue: | 1 |
| Article number: | 146 |
| DOI: | 10.1186/s12877-022-02836-8 |
| OADOI: | https://oadoi.org/10.1186/s12877-022-02836-8 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
The Sigrid Juselius Foundation and Paulo Foundation, both in Helsinki, Finland. |
| Copyright information: |
© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://creativecommons.org/licenses/by/4.0/ |