University of Oulu

Aryapour, E., & Kietzmann, T. (2022). Mitochondria, mitophagy, and the role of deubiquitinases as novel therapeutic targets in liver pathology. Journal of Cellular Biochemistry, 123(10), 1634–1646.

Mitochondria, mitophagy, and the role of deubiquitinases as novel therapeutic targets in liver pathology

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Author: Aryapour, Elham1; Kietzmann, Thomas1
Organizations: 1Faculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
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Language: English
Published: John Wiley & Sons, 2022
Publish Date: 2023-03-13


Liver diseases such as nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma (HCC) have increased over the past few decades due to the absence or ineffective therapeutics. Recently, it has been shown that inappropriate regulation of hepatic mitophagy is linked to the pathogenesis of the above-mentioned liver diseases. As mitophagy maintains cellular homeostasis by removing damaged and nonfunctional mitochondria from the cell, the proper function of the molecules involved are of utmost importance. Thereby, mitochondrial E3 ubiquitin ligases as well as several deubiquitinases (DUBs) appear to play a unique role for the degradation of mitochondrial proteins and for proper execution of the mitophagy process by either adding or removing ubiquitin chains from target proteins. Therefore, these enzymes could be considered as valuable liver disease biomarkers and also as novel targets for therapy. In this review, we focus on the role of different DUBs on mitophagy and their contribution to NAFLD, NASH, alcohol-related liver disease, and especially HCC.

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Series: Journal of cellular biochemistry
ISSN: 0730-2312
ISSN-E: 1097-4644
ISSN-L: 0730-2312
Volume: 123
Issue: 10
Pages: 1634 - 1646
DOI: 10.1002/jcb.30312
Type of Publication: A1 Journal article – refereed
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: The work in the authors laboratory was supported by grants from the Finnish Center of International Mobility, Finnish Academy of Sciences (SA296027), Jane and Aatos Erkko Foundation, Finnish Cancer Foundation, Sigrid Juselius Foundation, Biocenter Oulu, and University of Oulu.
Academy of Finland Grant Number: 296027
Detailed Information: 296027 (Academy of Finland Funding decision)
Copyright information: © 2022 The Authors. Journal of Cellular Biochemistry published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.