University of Oulu

Ommati, M.M., Mobasheri, A., Ma, Y. et al. Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation. Naunyn-Schmiedeberg's Arch Pharmacol 395, 1557–1572 (2022).

Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation

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Author: Ommati, Mohammad Mehdi1,2; Mobasheri, Ali3,4,5; Ma, Yanqin1;
Organizations: 1College of Life Sciences, Shanxi Agricultural University, Taigu, 030801, Shanxi, China
2Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Physics, and Technology, Faculty of Medicine, Research Unit of Medical Imaging, University of Oulu, 90014, Oulu, Finland
4Departments of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands
5Department of Regenerative Medicine, State Research Institute Center for Innovative Medicine, 08406, Vilnius, Lithuania
6Department of Biotechnology, GITAM Institute of Science, Gandhi Institute of Technology and Management, Visakhapatnam-530045, Andhra Pradesh, India
7Food and Drug Administration, Iran Ministry of Health and Medical Education, Tehran, Iran
8Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Format: article
Version: accepted version
Access: embargoed
Persistent link:
Language: English
Published: Springer Nature, 2022
Publish Date: 2023-09-13


Lung injury is a significant complication associated with cholestasis/cirrhosis. This problem significantly increases the risk of cirrhosis-related morbidity and mortality. Hence, finding effective therapeutic options in this field has significant clinical value. Severe inflammation and oxidative stress are involved in the mechanism of cirrhosis-induced lung injury. Taurine (TAU) is an abundant amino acid with substantial anti-inflammatory and antioxidative properties. The current study was designed to evaluate the role of TAU in cholestasis-related lung injury. For this purpose, bile duct ligated (BDL) rats were treated with TAU (0.5 and 1% w: v in drinking water). Significant increases in the broncho-alveolar lavage fluid (BALF) level of inflammatory cells (lymphocytes, neutrophils, basophils, monocytes, and eosinophils), increased IgG, and TNF-α were detected in the BDL animals (14 and 28 days after the BDL surgery). Alveolar congestion, hemorrhage, and fibrosis were the dominant pulmonary histopathological changes in the BDL group. Significant increases in the pulmonary tissue biomarkers of oxidative stress, including reactive oxygen species formation, lipid peroxidation, increased oxidized glutathione levels, and decreased reduced glutathione, were also detected in the BDL rats. Moreover, significant myeloperoxidase activity and nitric oxide levels were seen in the lung of BDL rats. It was found that TAU significantly blunted inflammation, alleviated oxidative stress, and mitigated lung histopathological changes in BDL animals. These data suggest TAU as a potential protective agent against cholestasis/cirrhosis-related lung injury.

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Series: Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 0028-1298
ISSN-E: 1432-1912
ISSN-L: 0028-1298
Volume: 395
Issue: 12
Pages: 1557 - 1572
DOI: 10.1007/s00210-022-02291-7
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: This study was fnancially supported by the Vice-Chancellor of Research Afairs of Shiraz University of Medical Sciences, Shiraz, Iran (grants #23701/23031/23040/23028/16428), Shanxi Agricultural University (Youth Fund project of Applied Basic Research in Shanxi Province; K272104065), and Natural Science Foundation of Shanxi Province (grant no. 201901D111232). Ali Mobasheri is supported by the Academy of Finland Prof6 336449 grant awarded to the University of Oulu, the European Commission, and the European Structural and Social Funds (ES Struktūrinės Paramos) awarded through the Research Council of Lithuania (Lietuvos Mokslo Taryba) and the funding program: Attracting Foreign Researchers for Research Implementation (2018–2022), grant no 01.2.2-LMT-K-718–02-0022.
Copyright information: © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: