Vähätalo J, Holmström L, Pakanen L, Kaikkonen K, Perkiömäki J, Huikuri H, Junttila J: Temporal Trends in the Incidence and Characteristics of Sudden Cardiac Death among Subjects under 40 Years of Age in Northern Finland during 1998–2017. Cardiology 2022;147:328-331. doi: 10.1159/000522554
Temporal trends in the incidence and characteristics of sudden cardiac death among subjects under 40 years of age in Northern Finland during 1998–2017
|Author:||Vähätalo, Juha1; Holmström, Lauri1; Pakanen, Lasse2,3;|
1Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital., Oulu, Finland
2Forensic Medicine Unit, Finnish Institute for Health and Welfare, Oulu, Finland
3Department of Forensic Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu, Oulu, Finland
4Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital., Oulu, Finland;
5Biocenter Oulu, University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023031531829
|Publish Date:|| 2023-03-15
Background: Although the mean age of sudden cardiac death (SCD) victims has increased during recent decades, overall incidence has remained relatively stable. Small but very important proportion of SCDs occur in subjects under 40 years of age and temporal trends in the incidence and characteristics of SCD in this age-group are not well known.
Methods: The Fingesture study has prospectively gathered data from 5,869 consecutive autopsy verified SCD victims in Northern Finland during 1998–2017. On the basis of Finnish law, all who die unexpectedly undergo autopsy.
Results: Out of total 5,869 SCDs, 160 occurred in subjects under 40 years of age (3%) indicating a total incidence of 2.9/100,000/year. Incidence decreased during the study period: 4.0/100,000/year (n = 50) in 1998–2002, 3.7/100,000/year (n = 45) in 2003–2007, 2.5/100,000/year (n = 36) in 2008–2012, and 1.5/100,000/year (n = 29) in 2013–2017. Coronary artery disease (CAD) was the cause of death in 46 SCD victims (29%). Among nonischemic causes, most common were obesity-related hypertrophic myocardial disease (24%), primary myocardial fibrosis (19%), and hypertensive myocardial disease (6%). The incidence of SCD caused by CAD decreased as follows: 1.5/100,000/year in 1998–2002, 1.2/100,000/year in 2003–2007, 0.6/100,000/year in 2008–2012, and 0.2/100,000/year in 2013–2017. Proportion of male gender (81%) and obesity as a comorbidity (body mass index >30 kg/m², 40%) remained relatively stable during the period (p = 0.58 and p = 0.79, respectively).
Conclusions: The incidence of SCD in subjects under 40 years of age has decreased in Northern Finland during 1998–2017. According to autopsy data, most of the deaths are due to nonischemic myocardial diseases and relative proportion of CAD has decreased.
|Pages:||328 - 331|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
This study received funding from Aarne Koskelo Foundation, Finnish Foundation for Cardiovascular Research, the Finnish Medical Foundation, Instrumentarium Science Foundation, the Maud Kuistila Memorial Foundation, the Ida Montin Foundation, the University of Oulu Scholarship Foundation, Paavo Nurmi Foundation, and Maire Taponen Foundation.
© 2022 S. Karger AG, Basel. The final, published version of this article is available at https://www.karger.com/?doi=10.1159/000522554.