University of Oulu

Koivusalo, S., Schmidt, A., Manninen, A., & Wenta, T. (2022). Regulation of kinase signaling pathways by α6β4-integrins and plectin in prostate cancer. Cancers, 15(1), 149.

Regulation of kinase signaling pathways by α6β4-integrins and plectin in prostate cancer

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Author: Koivusalo, Saara1; Schmidt, Anette1; Manninen, Aki1;
Organizations: 1Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland
2Department of General and Medical Biochemistry, Faculty of Biology, University of Gdansk, 80-308 Gdansk, Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.2 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2023
Publish Date: 2023-03-20


Hemidesmosomes (HDs) are adhesive structures that ensure stable anchorage of cells to the basement membrane. They are formed by α6β4-integrin heterodimers and linked to intermediate filaments via plectin. It has been reported that one of the most common events during the pathogenesis of prostate cancer (PCa) is the loss of HD organization. While the expression levels of β4-integrins are strongly reduced, the expression levels of α6-integrins and plectin are maintained or even elevated, and seem to promote tumorigenic properties of PCa cells, such as proliferation, invasion, metastasis, apoptosis- and drug-resistance. In this review, we discuss the potential mechanisms of how HD components might contribute to various cellular signaling pathways to promote prostate carcinogenesis. Moreover, we summarize the current knowledge on the involvement of α6β4-integrins and plectin in PCa initiation and progression.

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Series: Cancers
ISSN: 2072-6694
ISSN-E: 2072-6694
ISSN-L: 2072-6694
Volume: 15
Issue: 1
Article number: 149
DOI: 10.3390/cancers15010149
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3122 Cancers
1182 Biochemistry, cell and molecular biology
Funding: This work was funded by the Jane and Aatos Erkko Foundation (190046; AM), Cancer Foundation Finland (61-6158; AM), Biocenter Oulu and by the University of Oulu and Academy of Finland PROFI3 strategic program (AM).
Copyright information: © 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (