Danielewski, M., Żuraszek, J., Zielińska, A., Herzig, K.-H., Słomski, R., Walkowiak, J., & Wielgus, K. (2023). Methodological Changes in the Field of Paleogenetics. Genes, 14(1), 234. https://doi.org/10.3390/genes14010234
Methodological changes in the field of paleogenetics
|Author:||Danielewski, Mikołaj1; Żuraszek, Joanna2; Zielińska, Aleksandra2;|
1Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland
2Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland
3Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Medical Research Center, Oulu University Hospital, P.O. Box 5000, FIN-90014 Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023040535159
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2023-04-05
Paleogenetics has significantly changed since its inception almost forty years ago. Initially, molecular techniques available to the researchers offered minimal possibilities for ancient DNA analysis. The subsequent expansion of the scientific tool cabinet allowed for more remarkable achievements, combined has with the newfound popularity of this budding field of science. Finally, a breakthrough was made with the development of next-generation sequencing (NGS) technologies and the update of DNA isolation protocols, through which even very fragmented aDNA samples could be used to sequence whole genomes. In this paper, we review the achievements made thus far and compare the methodologies utilized in this field of science, discussing their benefits and challenges.
|Type of Publication:||
A2 Review article in a scientific journal
|Field of Science:||
1182 Biochemistry, cell and molecular biology
This research was funded by the National Centre of Science, grant number 2017/26/E/NZ5/00851.
© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).