University of Oulu

Danielewski, M., Żuraszek, J., Zielińska, A., Herzig, K.-H., Słomski, R., Walkowiak, J., & Wielgus, K. (2023). Methodological Changes in the Field of Paleogenetics. Genes, 14(1), 234.

Methodological changes in the field of paleogenetics

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Author: Danielewski, Mikołaj1; Żuraszek, Joanna2; Zielińska, Aleksandra2;
Organizations: 1Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland
2Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland
3Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Medical Research Center, Oulu University Hospital, P.O. Box 5000, FIN-90014 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2023
Publish Date: 2023-04-05


Paleogenetics has significantly changed since its inception almost forty years ago. Initially, molecular techniques available to the researchers offered minimal possibilities for ancient DNA analysis. The subsequent expansion of the scientific tool cabinet allowed for more remarkable achievements, combined has with the newfound popularity of this budding field of science. Finally, a breakthrough was made with the development of next-generation sequencing (NGS) technologies and the update of DNA isolation protocols, through which even very fragmented aDNA samples could be used to sequence whole genomes. In this paper, we review the achievements made thus far and compare the methodologies utilized in this field of science, discussing their benefits and challenges.

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Series: Genes
ISSN: 2073-4425
ISSN-E: 2073-4425
ISSN-L: 2073-4425
Volume: 14
Issue: 1
Article number: 234
DOI: 10.3390/genes14010234
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: This research was funded by the National Centre of Science, grant number 2017/26/E/NZ5/00851.
Copyright information: © 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (