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Risk factor profile in youth, genetic risk, and adulthood cognitive function : the Cardiovascular Risk in Young Finns Study |
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| Author: | Wu, Feitong1; Ahola-Olli, Ari2; Pahkala, Katja3,4,5; |
| Organizations: |
1Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia 2Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland 3Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland
4Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
5Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland 6Department of Medicine, University of Turku, Turku, Finland 7Division of Medicine, Turku University Hospital, Turku, Finland 8Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center - Tampere, Tampere University, Tampere, Finland 9Department of Pediatrics, Tampere University and Tampere University Hospital, Tampere, Finland 10Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland 11Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland 12Department of Pediatrics, University of Oulu, Oulu, Finland 13PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland 14Vaasa Central Hospital, Vaasa, Finland 15Department of Paediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland 16Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023041135881 |
| Language: | English |
| Published: |
Karger,
2022
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| Publish Date: | 2023-04-11 |
| Description: |
AbstractIntroduction: The role of risk factor profile in childhood and adolescence on adulthood cognitive function and whether it differs by genetic risk is still obscure. To bring this evidence, we determined cognitive domain-specific youth risk factor profiles leveraging the childhood/adolescence data from the Cardiovascular Risk in Young Finns Study and examined whether genetic propensity for poor cognitive function modifies the association between the risk profiles and adulthood cognitive function. Methods: From 1980, a population-based cohort of 3,596 children (age 3–18 years) has been repeatedly followed up for 31 years. Computerized cognitive test measuring (1) memory and learning, (2) short-term working memory, (3) reaction time, and (4) information processing was performed for 2,026 participants (age 34–49 years). Cognitive domain-specific youth risk profile scores, including physical and environmental factors, were assessed from the data collected at baseline and categorized into favourable, intermediate, and unfavourable. A polygenic risk score for a poor cognitive function was categorized into low, intermediate, and high risk. Results: At all genetic risk levels, a favourable youth risk factor profile is associated with better learning and memory, short-term working memory, and information processing compared to unfavourable risk profile (e.g., β = 0.501 SD, 95% CI: 0.043–0.959 for memory and learning among participants with high genetic risk). However, no significant interactions were observed between the youth risk factor profile score and genetic propensity for any cognitive domain (p > 0.299 for all). Conclusions: A favourable youth risk factor profile may be beneficial for cognitive function in adulthood, irrespective of genetic propensity for poor cognitive function. see all
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| Series: |
Neuroepidemiology |
| ISSN: | 0251-5350 |
| ISSN-E: | 1423-0208 |
| ISSN-L: | 0251-5350 |
| Volume: | 56 |
| Issue: | 3 |
| Pages: | 201 - 211 |
| DOI: | 10.1159/000524986 |
| OADOI: | https://oadoi.org/10.1159/000524986 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics 3111 Biomedicine |
| Subjects: | |
| Funding: |
The Young Finns Study has been financially supported by the Academy of Finland: Grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (Grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (Grant 755320 for TAXINOMISIS and grant 848146 ToAition); European Research Council (Grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation. F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.P. is supported by the Academy of Finland research fellowship (322112). |
| Copyright information: |
© 2022 S. Karger AG, Basel. |