University of Oulu

Stavtsev, D.D., Konovalov, A.N., Blinova, E.V. et al. Laser Speckle Contrast Imaging for Intraoperative Monitoring of Cerebral Blood Flow. Bull. Russ. Acad. Sci. Phys. 86 (Suppl 1), S229–S233 (2022).

Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow

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Author: Stavtsev, D. D.1,2; Konovalov, A. N.3; Blinova, E. V.1;
Organizations: 1Sechenov First Moscow State Medical University, 119991, Moscow, Russia
2National Research University of Electronic Technology, Institute of Biomedical Systems, 124498, Moscow, Russia
3Burdenko Neurosurgical Center, 125047, Moscow, Russia
4Negovsky Scientific Research Institute of General Reanimatology, Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, 107031, Moscow, Russia
5Optoelectronics and Measurement Techniques, University of Oulu, 90014, Oulu, Finland
6College of Engineering and Physical Sciences, Aston University, Birmingham, B91 3HB, UK
Format: article
Version: accepted version
Access: embargoed
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Language: English
Published: Allerton Press, 2022
Publish Date: 2024-01-12


Intraoperative monitoring of cerebral blood flow provides an important information required for clinicians to select optimal tactics during the neurosurgery procedures, including clipping cerebral vessel aneurysms, bypass, and arteriovenous malformation surgery. Presently, robust cost-effective non-invasive optical imaging techniques suitable to assess cerebral blood flow in the operating room do not exist. In current study we report a development of prototype of the Laser Speckle Contrast Imaging (LSCI) system as a complementary tool for non-invasive real-time visualization and quantitative assessment of cerebral blood flow during neurovascular surgery. The LSCI is based on the scattering of coherent laser light within dynamic turbid medium, such as biological tissues, including brain. The speckle patterns appeared due to interference of partial components of the dynamically scattered light are recorded by digital camera. To observe blood flow in large and small vessels as well as in the microcirculatory bed of the cerebral cortex the recorded images are quantitatively analyzed utilizing low-order statistical moment, known as imaging contrast or enhancement of visibility. The purpose of current pilot study is to assess general feasibility of the LSCI approach in terms technical abilities of image acquisition, its quality evaluation and further implication to day-to-day clinical practice.

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Series: Bulletin of the Russian Academy of Sciences. Physics
ISSN: 1062-8738
ISSN-E: 1934-9432
ISSN-L: 1062-8738
Volume: 86
Issue: Suppl 1
Pages: S229 - S233
DOI: 10.3103/S1062873822700733
Type of Publication: A1 Journal article – refereed
Field of Science: 213 Electronic, automation and communications engineering, electronics
Funding: The study was supported by the Russian Science Foundation (project no. 22-65-00096,
Copyright information: © Allerton Press, Inc., 2022. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: