University of Oulu

Kuru, H., Jokelainen, J., Tasanen, K., & Huilaja, L. (2022). Risk of Non-cutaneous Cancers in Individuals with Basal Cell Carcinoma: A Population-based Cohort Study. Acta Dermato-Venereologica, 102, adv00826.

Risk of non-cutaneous cancers in individuals with basal cell carcinoma : a population-based cohort study

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Author: Kuru, Hanna1,2; Jokelainen, Jari3,4; Tasanen, Kaisa1,2;
Organizations: 1Department of Dermatology, University Hospital of Oulu
2Medical Research Center, PEDEGO Research Group, University of Oulu
3Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu
4Unit of General Practice, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Society for Publication of Acta Dermato-Venereologica, 2022
Publish Date: 2023-04-21


Evidence of the association between a personal history of basal cell carcinoma and the risk of non-cutaneous malignancies is conflicting. The aim of this study was to retrospectively clarify the risk of non-cutaneous cancers in individuals with basal cell carcinoma using nationwide Finnish registry data for 96,304 patients and 394,503 randomly selected population controls. In this study, individuals with basal cell carcinoma have an increased risk of other cancers (odds ratio (OR) 1.38; 95% confidence interval (95% CI) 1.36–1.40). The risk was most prominent for lip cancer (OR 5.29; 95% CI 4.50–6.21), mycosis fungoides (OR 3.13; 95% CI 2.31–4.23) and soft tissue cancers (OR 2.77; 95% CI 2.43–3.16). In age-adjusted model, men had higher risk of cancers overall compared with women (p< 0.05). In conclusion, the study found increased overall cancer risk among patients with basal cell carcinoma compared with randomly selected population controls.

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Series: Acta dermato-venereologica
ISSN: 0001-5555
ISSN-E: 1651-2057
ISSN-L: 0001-5555
Volume: 102
Article number: adv00826
DOI: 10.2340/actadv.v102.4451
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3122 Cancers
Copyright information: © The Authors 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International Licens