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Association of physical activity with metabolic profile from adolescence to adulthood |
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| Author: | Lehtovirta, Miia1,2; Wu, Feitong3; Rovio, Suvi P.1,2; |
| Organizations: |
1Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland 2Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland 3Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
4Paavo Nurmi Centre, Unit for Health and Physical Activity, University of Turku, Turku, Finland
5Department of Pediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, Turku, Finland 6Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland 7Department of Medicine, University of Turku, Turku, Finland 8Division of Medicine, Turku University Hospital, Turku, Finland 9Department of Chronic Disease Prevention, Institute for Health and Welfare, Turku, Finland 10Computational Medicine, Center for Life Course Health Research, Faculty of Medicine, University of Oulu & Biocenter Oulu, Oulu, Finland 11NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland 12Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, Turku, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | embargoed |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023042739083 |
| Language: | English |
| Published: |
John Wiley & Sons,
2023
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| Publish Date: | 2024-02-12 |
| Description: |
AbstractObjective: Physical activity benefits cardiometabolic health, but little is known about its detailed links with serum lipoproteins, amino acids, and glucose metabolism at young age. We therefore studied the association of physical activity with a comprehensive metabolic profile measured repeatedly in adolescence. Methods: The cohort is derived from the longitudinal Special Turku Coronary Risk Factor Intervention Project. At ages 13, 15, 17, and 19 years, data on physical activity were collected by a questionnaire, and circulating metabolic measures were quantified by nuclear magnetic resonance metabolomics from repeatedly assessed serum samples (age 13: n = 503, 15: n = 472, 17: n = 466, and 19: n = 361). Results: Leisure-time physical activity (LTPA;MET h/wk) was directly associated with concentrations of polyunsaturated fatty acids, and inversely with the ratio of monounsaturated fatty acids to total fatty acids (−0.006SD; [−0.008, −0.003]; p < 0.0001). LTPA was inversely associated with very-low-density lipoprotein (VLDL) particle concentration (−0.003SD; [−0.005, −0.001]; p = 0.002) and VLDL particle size (−0.005SD; [−0.007, −0.003]; p < 0.0001). LTPA showed direct association with the particle concentration and size of high-density lipoprotein (HDL), and HDL cholesterol concentration (0.004SD; [0.002, 0.006]; p < 0.0001). Inverse associations of LTPA with triglyceride and total lipid concentrations in large to small sized VLDL subclasses were found. Weaker associations were seen for other metabolic measures including inverse associations with concentrations of lactate, isoleucine, glycoprotein acetylation, and a direct association with creatinine concentration. The results remained after adjusting for body mass index and proportions of energy intakes from macronutrients. Conclusions: Physical activity during adolescence is beneficially associated with the metabolic profile including novel markers. The results support recommendations on physical activity during adolescence to promote health and possibly reduce future disease risks. see all
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| Series: |
Scandinavian journal of medicine & science in sports |
| ISSN: | 0905-7188 |
| ISSN-E: | 1600-0838 |
| ISSN-L: | 0905-7188 |
| Volume: | 33 |
| Issue: | 3 |
| Pages: | 307 - 318 |
| DOI: | 10.1111/sms.14261 |
| OADOI: | https://oadoi.org/10.1111/sms.14261 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3142 Public health care science, environmental and occupational health |
| Subjects: | |
| Funding: |
This work was supported by the Academy of Finland (grant numbers: 206374, 294834, 251360, 275595, 307996, and 322112); the Juho Vainio Foundation; the Finnish Foundation for Cardiovascular Research; the Finnish Ministry of Education and Culture; the Finnish Cultural Foundation; the Sigrid Jusélius Foundation; Special Governmental grants for Health Sciences Research, Turku University Hospital; the Yrjö Jahnsson Foundation; the Finnish Medical Foundation; and the Turku University Foundation. MAK has a research grant from the Sigrid Jusélius Foundation. |
| Academy of Finland Grant Number: |
294834 |
| Detailed Information: |
294834 (Academy of Finland Funding decision) |
| Copyright information: |
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Lehtovirta, M, Wu, F, Rovio, SP, et al. Association of physical activity with metabolic profile from adolescence to adulthood. Scand J Med Sci Sports. 2023; 33: 307- 318, which has been published in final form at https://doi.org/10.1111/sms.14261. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |