|
|
Duration of clinical symptoms in children with acute respiratory infection |
|---|---|
| Author: | Paalanne, Niko1,2; Honkila, Minna1,2; Mattila, Suvi1,2; |
| Organizations: |
1Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland 2Research Unit of Clinical Medicine and Medical Research Centre, University of Oulu, Oulu, Finland 3Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
4Biocenter Oulu, University of Oulu, Oulu, Finland
|
| Format: | article |
| Version: | accepted version |
| Access: | embargoed |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023042739102 |
| Language: | English |
| Published: |
John Wiley & Sons,
2023
|
| Publish Date: | 2024-03-10 |
| Description: |
AbstractAim: To investigate duration of clinical symptoms associated with various respiratory viruses and with the co-detection of respiratory viral and bacterial pathogens. Methods: This prospective cohort study included 737 acutely ill children treated in a paediatric emergency department prior to the COVID-19 pandemic. Nasal swab samples were analysed with multiplex PCR panels for 16 viral and 7 bacterial respiratory pathogens. Parents filled in a questionnaire about the symptoms at the time of the visit and 14 days afterwards. Results: Persistent symptoms 2 weeks after the onset of acute illness were common: 32% of the patients with a coronavirus 229 E, NL63 or OC43 finding, 31% of those with human metapneumovirus and 25% of those with rhinovirus reported ongoing symptoms. At least one symptom lasting more than 4 weeks was observed in 3–4% of the children. Children with viral and bacterial co-detection had a longer duration of fever than those with only viral detection (3.3 days [SD 2.8] vs. 1.6 days [SD 2.4], p < 0.001). Conclusion: Symptoms lasting for more than 2 to 4 weeks appear to be relatively frequent in all respiratory viral infections in children. Viral and bacterial co-detection may increase the duration of illness. see all
|
| Series: |
Acta pædiatrica |
| ISSN: | 0803-5253 |
| ISSN-E: | 1651-2227 |
| ISSN-L: | 0803-5253 |
| Volume: | 112 |
| Issue: | 4 |
| Pages: | 813 - 819 |
| DOI: | 10.1111/apa.16607 |
| OADOI: | https://oadoi.org/10.1111/apa.16607 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
Funding was received from the Alma and K.A. Snellman Foundation, Finland (Niko Paalanne, Terhi Tapiainen), the Finnish Medical Foundation, Finland (Niko Paalanne) and the Academy of Finland (Terhi Tapiainen). None of these sources had any role in the design or execution of the study. |
| Copyright information: |
© 2022 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Paalanne, N, Honkila, M, Mattila, S, Pokka, T, Renko, M, Tapiainen, T. Duration of clinical symptoms in children with acute respiratory infection. Acta Paediatr. 2023; 112: 813– 819, which has been published in final form at https://doi.org/10.1111/apa.16607. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |