University of Oulu

Jokimäki, A, Iivanainen, S, Mikkonen, R, Mika, K, Koivunen, J. Assessment of chemotherapy-induced neurotoxicity using a point-of-care nerve conduction study device. Cancer Reports. 2023; 6( 1):e1677. doi:10.1002/cnr2.1677

Assessment of chemotherapy-induced neurotoxicity using a point-of-care nerve conduction study device

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Author: Jokimäki, Anna1,2,3; Iivanainen, Sanna1,3; Mikkonen, Raija1;
Organizations: 1Department of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland
2Institute of Clinical Medicine, Faculty of Health Medicine, University of Eastern Finland, Kuopio, Finland
3Medical Research Center, Oulu University Hospital and Cancer and Translational Research Unit, University of Oulu, Oulu, Finland
4Department of Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
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Language: English
Published: John Wiley & Sons, 2023
Publish Date: 2023-05-04


Background: Management for chemotherapy-induced peripheral neuropathy (CIPN) includes prompt recognition and dose reduction or discontinuation of the neurotoxic agents. CIPN remains under-detected in routine clinical practice and better methods for its early detection are warranted.

Aims: To evaluate the feasibility of a point-of-care device in the early detection of CIPN.

Methods and Results: Cancer patients (n = 12) scheduled to receive neurotoxic chemotherapy docetaxel, oxaliplatin (OX), or vincristine were recruited for the pilot study (NCT04778878). The patients were assessed with a point-of-care nerve conduction study device (Mediracer® NCS), EORTC QLQ-CIPN20 and NPSI questionnaires, and healthcare professional-assessed CTCAE-based grading at baseline and thereafter every 6-weeks up to 18 weeks or until chemotherapy discontinuation. The set-up of point-of-care device was easy but it only provide successful NCS measurement results in 55% of the patients. The factors related to failed measurement were older age, more frequent comorbidities, and a history of smoking. With the follow-up measurements, decreasing median nerve mean conduction velocity and amplitude, and increasing median nerve mean distal latency were detected on OX-patients. Of the used questionnaires, NPSI was found to be non-feasible with majority of the patients failing to complete the questionnaire while CIPN20 was feasible on all the subjects. CIPN20 score did not show any changes in the follow-up.

Conclusions: Point-of-care assessment for NCS was feasible but measurements frequently failed especially on patients with pre-existing high-risk for neuropathy. OX-treated showed decreasing NCS results while other measures were unable to access the change. The system should be further validated with a larger patient cohort preferably treated with OX and low-risk for pre-existing neuropathy.

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Series: Cancer reports
ISSN: 2573-8348
ISSN-E: 2573-8348
ISSN-L: 2573-8348
Volume: 6
Issue: 1
Article number: e1677
DOI: 10.1002/cnr2.1677
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
3122 Cancers
Funding: This work was supported by the University of Oulu and Oulu University Hospital.
Copyright information: © 2022 The Authors. Cancer Reports published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.