University of Oulu

Keskitalo, Eerika BM; Salonen, Johanna MD, PhD; Nurmi, Hanna MD, PhD; Vähänikkilä, Hannu PhD; Kaarteenaho, Riitta MD, PhD. Comorbidities and Causes of Death of Patients With Asbestosis. Journal of Occupational and Environmental Medicine 65(4):p 349-353, April 2023. | DOI: 10.1097/JOM.0000000000002777

Comorbidities and causes of death of patients with asbestosis

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Author: Keskitalo, Eerika1,2; Salonen, Johanna1,2; Nurmi, Hanna3,4;
Organizations: 1Research Unit of Internal Medicine, University of Oulu, Oulu, Finland
2Center of Internal and Respiratory Medicine, Medical Research Center (MRC) Oulu, Oulu, Finland
3Division of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
4Center of Medicine and Clinical Research, Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
5Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population studies, Faculty of Medicine, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link:
Language: English
Published: Wolters Kluwer, 2023
Publish Date: 2023-12-22


Objective: Comorbidities are common and affect the prognosis of patients with interstitial lung diseases, but few previous studies have investigated patients with asbestosis.

Methods: We collected comorbidities and death causes of 116 patients with asbestosis treated in Oulu University Hospital. Causes of death were confirmed by autopsy in 68% of the cases.

Results: The most common comorbidities of asbestosis patients were pleural plaques (96%) and coronary artery disease (CAD; 67%). The prevalence of rheumatoid arthritis was 8.6%. The most common underlying causes of death were asbestosis (36%), CAD (24%), and lung cancer (LC) (10%). CAD and LC were associated with shorter survival in adjusted analyses.

Conclusions: Patients with asbestosis have multiple comorbidities. Prevention and treatment of CAD and LC may influence the prognosis of asbestosis patients.

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Series: Journal of occupational and environmental medicine
ISSN: 1076-2752
ISSN-E: 1536-5948
ISSN-L: 1076-2752
Volume: 65
Issue: 4
Pages: 349 - 353
DOI: 10.1097/JOM.0000000000002777
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: E.K. has received grants for scientific work from the Research Foundation of Pulmonary Diseases and the Foundation of the Finnish Anti-Tuberculosis Association. H.N. reports grants from the Foundation of the Finnish Anti-Tuberculosis Association and the North Savo Regional Fund of the Finnish Cultural Foundation outside the current work. R.K. has received grants for the study group from the Foundation of the Finnish Anti-Tuberculosis Association, the Research Foundation of Pulmonary Diseases, the Research Foundation of North Finland, the Jalmari and Rauha Ahokas Foundation, and a state subsidy of the Oulu University Hospital. The funding bodies have not affected the contents of this study.
Copyright information: © 2022 American College of Occupational and Environmental Medicine.